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A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

Author

Listed:
  • Alassane Mbengue

    (Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
    University of Notre Dame)

  • Souvik Bhattacharjee

    (Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
    University of Notre Dame)

  • Trupti Pandharkar

    (Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
    University of Notre Dame)

  • Haining Liu

    (Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
    University of Notre Dame)

  • Guillermina Estiu

    (Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
    University of Notre Dame)

  • Robert V. Stahelin

    (Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
    University of Notre Dame
    Indiana University School of Medicine-South Bend)

  • Shahir S. Rizk

    (Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
    University of Notre Dame)

  • Dieudonne L. Njimoh

    (Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
    University of Notre Dame
    Departmen of. Biochemistry and Molecular Biology, Faculty of Science University of Buea)

  • Yana Ryan

    (Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
    University of Notre Dame)

  • Kesinee Chotivanich

    (Faculty of Tropical Medicine, Mahidol University)

  • Chea Nguon

    (National Center for Parasitology, Entomology and Malaria Control)

  • Mehdi Ghorbal

    (CNRS 5290/IRD 224/University Montpellier 1&2 (“MiVEGEC”))

  • Jose-Juan Lopez-Rubio

    (CNRS 5290/IRD 224/University Montpellier 1&2 (“MiVEGEC”))

  • Michael Pfrender

    (University of Notre Dame)

  • Scott Emrich

    (University of Notre Dame)

  • Narla Mohandas

    (New York Blood Center)

  • Arjen M. Dondorp

    (Faculty of Tropical Medicine, Mahidol University
    Centre for Tropical Medicine, University of Oxford)

  • Olaf Wiest

    (Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
    University of Notre Dame
    Laboratory of Computational Chemistry and Drug Design, Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School)

  • Kasturi Haldar

    (Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
    University of Notre Dame)

Abstract

Artemisinins are key anti-malarial drugs, but artemisinin resistance has been increasing; this study identifies the molecular target of artemisinins as phosphatidylinositol-3-kinase and increase of the lipid product phosphatidylinositol-3-phosphate induces resistance in Plasmodium falciparum.

Suggested Citation

  • Alassane Mbengue & Souvik Bhattacharjee & Trupti Pandharkar & Haining Liu & Guillermina Estiu & Robert V. Stahelin & Shahir S. Rizk & Dieudonne L. Njimoh & Yana Ryan & Kesinee Chotivanich & Chea Nguon, 2015. "A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria," Nature, Nature, vol. 520(7549), pages 683-687, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7549:d:10.1038_nature14412
    DOI: 10.1038/nature14412
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    Cited by:

    1. George Tzotzos & Jim N Iley & Elaine A Moore, 2018. "New insights on repellent recognition by Anopheles gambiae odorant-binding protein 1," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-23, April.

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