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Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

Author

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  • Umeharu Ohto

    (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Takuma Shibata

    (Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Saitama 332-0012, Japan)

  • Hiromi Tanji

    (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Hanako Ishida

    (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Elena Krayukhina

    (Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan
    U-Medico Corporation, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Susumu Uchiyama

    (Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Kensuke Miyake

    (Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan)

  • Toshiyuki Shimizu

    (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Saitama 332-0012, Japan)

Abstract

Crystal structures of three forms of Toll-like receptor (TLR) 9 — unliganded or bound either to immune stimulatory CpG-containing DNA or inhibitory DNA — together reveal the molecular basis of TLR9 activation.

Suggested Citation

  • Umeharu Ohto & Takuma Shibata & Hiromi Tanji & Hanako Ishida & Elena Krayukhina & Susumu Uchiyama & Kensuke Miyake & Toshiyuki Shimizu, 2015. "Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9," Nature, Nature, vol. 520(7549), pages 702-705, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7549:d:10.1038_nature14138
    DOI: 10.1038/nature14138
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    Cited by:

    1. Srujan Kumar Dondapati & Georg Pietruschka & Lena Thoring & Doreen A Wüstenhagen & Stefan Kubick, 2019. "Cell-free synthesis of human toll-like receptor 9 (TLR9): Optimization of synthesis conditions and functional analysis," PLOS ONE, Public Library of Science, vol. 14(4), pages 1-16, April.
    2. F. D. Kornilov & A. V. Shabalkina & Cong Lin & P. E. Volynsky & E. F. Kot & A. L. Kayushin & V. A. Lushpa & M. V. Goncharuk & A. S. Arseniev & S. A. Goncharuk & Xiaohui Wang & K. S. Mineev, 2023. "The architecture of transmembrane and cytoplasmic juxtamembrane regions of Toll-like receptors," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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