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Super-enhancers delineate disease-associated regulatory nodes in T cells

Author

Listed:
  • Golnaz Vahedi

    (Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH))

  • Yuka Kanno

    (Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH))

  • Yasuko Furumoto

    (Translational Immunology Section, NIAMS, NIH, Bethesda, Maryland 20892, USA)

  • Kan Jiang

    (Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH))

  • Stephen C. J. Parker

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
    Present address: Departments of Computational Medicine & Bioinformatics and Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.)

  • Michael R. Erdos

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA)

  • Sean R. Davis

    (Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Rahul Roychoudhuri

    (Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Nicholas P. Restifo

    (Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Massimo Gadina

    (Translational Immunology Section, NIAMS, NIH, Bethesda, Maryland 20892, USA)

  • Zhonghui Tang

    (University of Connecticut)

  • Yijun Ruan

    (University of Connecticut)

  • Francis S. Collins

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA)

  • Vittorio Sartorelli

    (Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, NIH, Bethesda, Maryland 20892, USA)

  • John J. O’Shea

    (Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH))

Abstract

A study of the super-enhancer landscape in three mouse T-helper lymphocyte subsets identifies nodes that have key roles in cell identity, with the locus encoding Bach2, a key negative regulator of effector differentiation, emerging as the most prominent T-cell super-enhancer.

Suggested Citation

  • Golnaz Vahedi & Yuka Kanno & Yasuko Furumoto & Kan Jiang & Stephen C. J. Parker & Michael R. Erdos & Sean R. Davis & Rahul Roychoudhuri & Nicholas P. Restifo & Massimo Gadina & Zhonghui Tang & Yijun R, 2015. "Super-enhancers delineate disease-associated regulatory nodes in T cells," Nature, Nature, vol. 520(7548), pages 558-562, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7548:d:10.1038_nature14154
    DOI: 10.1038/nature14154
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    Cited by:

    1. Sora Yoon & Aditi Chandra & Golnaz Vahedi, 2022. "Stripenn detects architectural stripes from chromatin conformation data using computer vision," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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