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ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

Author

Listed:
  • Jiajie Diao

    (Stanford University
    Stanford University
    Stanford University
    Stanford University)

  • Rong Liu

    (Center for Autophagy Research, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center
    College of Food Science & Nutritional Engineering, China Agricultural University)

  • Yueguang Rong

    (Center for Autophagy Research, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Minglei Zhao

    (Stanford University
    Stanford University
    Stanford University
    Stanford University)

  • Jing Zhang

    (Center for Autophagy Research, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Ying Lai

    (Stanford University
    Stanford University
    Stanford University
    Stanford University)

  • Qiangjun Zhou

    (Stanford University
    Stanford University
    Stanford University
    Stanford University)

  • Livia M. Wilz

    (Biophysics and Structural Biology, University of California at Berkeley)

  • Jianxu Li

    (Biophysics and Structural Biology, University of California at Berkeley)

  • Sandro Vivona

    (Stanford University
    Stanford University
    Stanford University
    Stanford University)

  • Richard A. Pfuetzner

    (Stanford University
    Stanford University
    Stanford University
    Stanford University)

  • Axel T. Brunger

    (Stanford University
    Stanford University
    Stanford University
    Stanford University)

  • Qing Zhong

    (Center for Autophagy Research, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

Abstract

The essential autophagy mediator ATG14 promotes vesicle fusion by forming homo-oligomers, which bind to a component of the SNARE membrane fusion complex and stabilize this complex on autophagosomes.

Suggested Citation

  • Jiajie Diao & Rong Liu & Yueguang Rong & Minglei Zhao & Jing Zhang & Ying Lai & Qiangjun Zhou & Livia M. Wilz & Jianxu Li & Sandro Vivona & Richard A. Pfuetzner & Axel T. Brunger & Qing Zhong, 2015. "ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes," Nature, Nature, vol. 520(7548), pages 563-566, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7548:d:10.1038_nature14147
    DOI: 10.1038/nature14147
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    Citations

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    Cited by:

    1. Catherine J. Greene & Jenny A. Nguyen & Samuel M. Cheung & Corey R. Arnold & Dale R. Balce & Ya Ting Wang & Adrian Soderholm & Neil McKenna & Devin Aggarwal & Rhiannon I. Campden & Benjamin W. Ewanchu, 2022. "Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Zhen Yuan & Kun Cai & Jiajia Li & Ruifeng Chen & Fuhai Zhang & Xuan Tan & Yaming Jiu & Haishuang Chang & Bing Hu & Weiyi Zhang & Binbin Ding, 2024. "ATG14 targets lipid droplets and acts as an autophagic receptor for syntaxin18-regulated lipid droplet turnover," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Marika K. Kucińska & Juliette Fedry & Carmela Galli & Diego Morone & Andrea Raimondi & Tatiana Soldà & Friedrich Förster & Maurizio Molinari, 2023. "TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Hong Huang & Qinqin Ouyang & Min Zhu & Haijia Yu & Kunrong Mei & Rong Liu, 2021. "mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    5. Patricia González-Rodríguez & Daniel J. Klionsky & Bertrand Joseph, 2022. "Autophagy regulation by RNA alternative splicing and implications in human diseases," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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