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SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Author

Listed:
  • Dohoon Kim

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT))

  • Brian P. Fiske

    (The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT)
    Broad Institute of Harvard and MIT, Seven Cambridge Center)

  • Kivanc Birsoy

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT))

  • Elizaveta Freinkman

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT))

  • Kenjiro Kami

    (Human Metabolome Technologies, Inc.)

  • Richard L. Possemato

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT))

  • Yakov Chudnovsky

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT))

  • Michael E. Pacold

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT))

  • Walter W. Chen

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT))

  • Jason R. Cantor

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT))

  • Laura M. Shelton

    (Human Metabolome Technologies America, Inc.)

  • Dan Y. Gui

    (The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT)
    Broad Institute of Harvard and MIT, Seven Cambridge Center)

  • Manjae Kwon

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology (MIT))

  • Shakti H. Ramkissoon

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital
    Boston Children’s Hospital)

  • Keith L. Ligon

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital
    Boston Children’s Hospital)

  • Seong Woo Kang

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT))

  • Matija Snuderl

    (NYU Langone Medical Center and Medical School)

  • Matthew G. Vander Heiden

    (The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT)
    Broad Institute of Harvard and MIT, Seven Cambridge Center
    Dana-Farber Cancer Institute)

  • David M. Sabatini

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    The David H. Koch Institute for Integrative Cancer Research at MIT
    Massachusetts Institute of Technology (MIT))

Abstract

Tumours are a low-oxygen environment, in this study glioblastoma cells are found to overexpress the serine hydroxymethyltransferase SHMT2; SHMT acts to reduce oxygen consumption, which confers the tumour cells with a survival advantage.

Suggested Citation

  • Dohoon Kim & Brian P. Fiske & Kivanc Birsoy & Elizaveta Freinkman & Kenjiro Kami & Richard L. Possemato & Yakov Chudnovsky & Michael E. Pacold & Walter W. Chen & Jason R. Cantor & Laura M. Shelton & D, 2015. "SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance," Nature, Nature, vol. 520(7547), pages 363-367, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7547:d:10.1038_nature14363
    DOI: 10.1038/nature14363
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    Cited by:

    1. Seong Eun Lee & Seongyeol Park & Shinae Yi & Na Rae Choi & Mi Ae Lim & Jae Won Chang & Ho-Ryun Won & Je Ryong Kim & Hye Mi Ko & Eun-Jae Chung & Young Joo Park & Sun Wook Cho & Hyeong Won Yu & June You, 2024. "Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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