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Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation

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  • J. Marsolier

    (Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France)

  • M. Perichon

    (Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France)

  • J. D. DeBarry

    (Center for Tropical and Emerging Global Diseases, University of Georgia)

  • B. O. Villoutreix

    (Université Paris Diderot, Sorbonne Paris Cité, Molécules Thérapeutiques in silico, INSERM UMR-S 973, 75013 Paris, France)

  • J. Chluba

    (INSERM, UMR 866, Equipe labellisée Ligue contre le Cancer and Laboratoire d’Excellence LipSTIC, 21000 Dijon, France
    University of Burgundy, Faculty of Medicine and Pharmacy, 21000 Dijon, France)

  • T. Lopez

    (INSERM, UMR 866, Equipe labellisée Ligue contre le Cancer and Laboratoire d’Excellence LipSTIC, 21000 Dijon, France
    University of Burgundy, Faculty of Medicine and Pharmacy, 21000 Dijon, France)

  • C. Garrido

    (INSERM, UMR 866, Equipe labellisée Ligue contre le Cancer and Laboratoire d’Excellence LipSTIC, 21000 Dijon, France
    University of Burgundy, Faculty of Medicine and Pharmacy, 21000 Dijon, France
    Centre anticancéreux George François Leclerc, CGFL, 21000 Dijon, France)

  • X. Z. Zhou

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • K. P. Lu

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • L. Fritsch

    (Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France)

  • S. Ait-Si-Ali

    (Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France)

  • M. Mhadhbi

    (Laboratoire de Parasitologie, Ecole Nationale de Médecine Vétérinaire, Université de la Manouba, 2020 Sidi Thabet, Tunisia)

  • S. Medjkane

    (Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France)

  • J. B. Weitzman

    (Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France)

Abstract

Parasites of the Theileria genus infect cattle and transform their host cells, a transformation that can be reversed by treatment with the drug buparvaquone; here, a Theileria homologue of the peptidyl-prolyl isomerase PIN1 is shown to be secreted into the host cell, where it promotes transformation and can be directly inhibited by buparvaquone.

Suggested Citation

  • J. Marsolier & M. Perichon & J. D. DeBarry & B. O. Villoutreix & J. Chluba & T. Lopez & C. Garrido & X. Z. Zhou & K. P. Lu & L. Fritsch & S. Ait-Si-Ali & M. Mhadhbi & S. Medjkane & J. B. Weitzman, 2015. "Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation," Nature, Nature, vol. 520(7547), pages 378-382, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7547:d:10.1038_nature14044
    DOI: 10.1038/nature14044
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    Cited by:

    1. Marie Villares & Nelly Lourenço & Ivan Ktorza & Jérémy Berthelet & Aristeidis Panagiotou & Aurélie Richard & Angélique Amo & Yulianna Koziy & Souhila Medjkane & Sergio Valente & Rossella Fioravanti & , 2024. "Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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