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The Paf1 complex represses small-RNA-mediated epigenetic gene silencing

Author

Listed:
  • Katarzyna Maria Kowalik

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    University of Basel, Petersplatz 10, 4003 Basel, Switzerland)

  • Yukiko Shimada

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    University of Basel, Petersplatz 10, 4003 Basel, Switzerland)

  • Valentin Flury

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    University of Basel, Petersplatz 10, 4003 Basel, Switzerland)

  • Michael Beda Stadler

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    University of Basel, Petersplatz 10, 4003 Basel, Switzerland
    Swiss Institute of Bioinformatics, Maulbeerstrasse 66, 4058 Basel, Switzerland)

  • Julia Batki

    (Eötvös Loránd University, Faculty of Sciences, Institute of Chemistry, 1/A Pázmány Péter sétány, Budapest 1117, Hungary)

  • Marc Bühler

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    University of Basel, Petersplatz 10, 4003 Basel, Switzerland)

Abstract

The fission yeast is shown to have a mechanism to prevent small RNAs from inducing heterochromatin and epigenetic gene silencing; this protective model involves the highly conserved Paf1 complex, which is known to promote transcription and processing of pre-mRNA, and protects protein-coding genes from unwanted silencing by spurious transcripts.

Suggested Citation

  • Katarzyna Maria Kowalik & Yukiko Shimada & Valentin Flury & Michael Beda Stadler & Julia Batki & Marc Bühler, 2015. "The Paf1 complex represses small-RNA-mediated epigenetic gene silencing," Nature, Nature, vol. 520(7546), pages 248-252, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7546:d:10.1038_nature14337
    DOI: 10.1038/nature14337
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