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Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

Author

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  • Tuncay Baubec

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

  • Daniele F. Colombo

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

  • Christiane Wirbelauer

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

  • Juliane Schmidt

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

  • Lukas Burger

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    Swiss Institute of Bioinformatics. Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

  • Arnaud R. Krebs

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

  • Altuna Akalin

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    Present address: Max Delbrück Center, The Berlin Institute for Medical Systems Biology, Robert Rössle Strasse 10, DE-13125 Berlin, Germany.)

  • Dirk Schübeler

    (Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    University of Basel, Faculty of Sciences, Petersplatz 1, CH-4001 Basel, Switzerland)

Abstract

Genome-wide localization and activity analysis of the de novo DNA methyltransferases DNMT3A and DNMT3B in mouse embryonic stem cells identifies overlapping and individual targeting preferences to the genome, including a role for DNMT3B in gene body methylation.

Suggested Citation

  • Tuncay Baubec & Daniele F. Colombo & Christiane Wirbelauer & Juliane Schmidt & Lukas Burger & Arnaud R. Krebs & Altuna Akalin & Dirk Schübeler, 2015. "Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation," Nature, Nature, vol. 520(7546), pages 243-247, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7546:d:10.1038_nature14176
    DOI: 10.1038/nature14176
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    Citations

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    Cited by:

    1. Jamie L. Endicott & Paula A. Nolte & Hui Shen & Peter W. Laird, 2022. "Cell division drives DNA methylation loss in late-replicating domains in primary human cells," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Yanting Luo & Jianlin He & Xiguang Xu & Ming-an Sun & Xiaowei Wu & Xuemei Lu & Hehuang Xie, 2018. "Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells," PLOS Computational Biology, Public Library of Science, vol. 14(3), pages 1-21, March.
    3. Antonella Fazio & Dora Bordoni & Jan W. P. Kuiper & Saskia Weber-Stiehl & Stephanie T. Stengel & Philipp Arnold & David Ellinghaus & Go Ito & Florian Tran & Berith Messner & Anna Henning & Joana P. Be, 2022. "DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Xiao Chen & Yinglu Li & Fang Zhu & Xinjing Xu & Brian Estrella & Manuel A. Pazos & John T. McGuire & Dimitris Karagiannis & Varun Sahu & Mustafo Mustafokulov & Claudio Scuoppo & Francisco J. Sánchez-R, 2023. "Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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