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Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

Author

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  • Shruti Naik

    (Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    Present addresses: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA.)

  • Nicolas Bouladoux

    (Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA)

  • Jonathan L. Linehan

    (Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA)

  • Seong-Ji Han

    (Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA)

  • Oliver J. Harrison

    (Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA)

  • Christoph Wilhelm

    (Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA)

  • Sean Conlan

    (Translational and Functional Genomics Branch, National Human Genome Research Institute)

  • Sarah Himmelfarb

    (Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA)

  • Allyson L. Byrd

    (Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    Translational and Functional Genomics Branch, National Human Genome Research Institute)

  • Clayton Deming

    (Translational and Functional Genomics Branch, National Human Genome Research Institute)

  • Mariam Quinones

    (Bioinformatics and Computational Bioscience Branch, National Institute of Allergy and Infectious Diseases)

  • Jason M. Brenchley

    (Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
    Immunopathogenesis Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases)

  • Heidi H. Kong

    (Dermatology Branch, National Cancer Institute)

  • Roxanne Tussiwand

    (Howard Hughes Medical Institute, Washington University School of Medicine)

  • Kenneth M. Murphy

    (Howard Hughes Medical Institute, Washington University School of Medicine)

  • Miriam Merad

    (Tisch Cancer Institute and Immunology Institute, Icahn School of Medicine at Mount Sinai)

  • Julia A. Segre

    (Translational and Functional Genomics Branch, National Human Genome Research Institute)

  • Yasmine Belkaid

    (Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA)

Abstract

Defined skin commensal bacteria elicit a dermal dendritic-cell-dependent, long-lasting, commensal-specific CD8+ T-cell response that promotes protection against pathogens while preserving tissue homeostasis.

Suggested Citation

  • Shruti Naik & Nicolas Bouladoux & Jonathan L. Linehan & Seong-Ji Han & Oliver J. Harrison & Christoph Wilhelm & Sean Conlan & Sarah Himmelfarb & Allyson L. Byrd & Clayton Deming & Mariam Quinones & Ja, 2015. "Commensal–dendritic-cell interaction specifies a unique protective skin immune signature," Nature, Nature, vol. 520(7545), pages 104-108, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7545:d:10.1038_nature14052
    DOI: 10.1038/nature14052
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    Cited by:

    1. Zheng Su & Dongdong Xu & Xianli Hu & Wanbo Zhu & Lingtong Kong & Zhengzheng Qian & Jiawei Mei & Ruixiang Ma & Xifu Shang & Wenpei Fan & Chen Zhu, 2024. "Biodegradable oxygen-evolving metalloantibiotics for spatiotemporal sono-metalloimmunotherapy against orthopaedic biofilm infections," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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