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Lineage correlations of single cell division time as a probe of cell-cycle dynamics

Author

Listed:
  • Oded Sandler

    (IMRIC, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel)

  • Sivan Pearl Mizrahi

    (IMRIC, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel)

  • Noga Weiss

    (Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel)

  • Oded Agam

    (Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel)

  • Itamar Simon

    (IMRIC, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel)

  • Nathalie Q. Balaban

    (Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem 91904, Israel)

Abstract

Precise measurement of cell-cycle duration in thousands of mammalian cells reveals correlations among cousin cells, but no such correlations between mother and daughter cells; recapitulating this finding using a deterministic model suggests that observed cellular heterogeneities in cell-cycle duration may be attributable to deterministic processes, and eventually be controlled.

Suggested Citation

  • Oded Sandler & Sivan Pearl Mizrahi & Noga Weiss & Oded Agam & Itamar Simon & Nathalie Q. Balaban, 2015. "Lineage correlations of single cell division time as a probe of cell-cycle dynamics," Nature, Nature, vol. 519(7544), pages 468-471, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7544:d:10.1038_nature14318
    DOI: 10.1038/nature14318
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    Cited by:

    1. Damien G Hicks & Terence P Speed & Mohammed Yassin & Sarah M Russell, 2019. "Maps of variability in cell lineage trees," PLOS Computational Biology, Public Library of Science, vol. 15(2), pages 1-32, February.
    2. Scharf, Yael, 2017. "A chaotic outlook on biological systems," Chaos, Solitons & Fractals, Elsevier, vol. 95(C), pages 42-47.

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