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The paraventricular thalamus controls a central amygdala fear circuit

Author

Listed:
  • Mario A. Penzo

    (Cold Spring Harbor Laboratory)

  • Vincent Robert

    (Cold Spring Harbor Laboratory
    Ecole Normale Supérieure de Cachan, 94230 Cachan, France)

  • Jason Tucciarone

    (Cold Spring Harbor Laboratory
    Medical Scientist Training Program & Program in Neuroscience, Stony Brook University)

  • Dimitri De Bundel

    (CNRS, UMR-5203, INSERM U661, Institut de Génomique Fonctionnelle, 34090 Montpellier, France
    Present address: Center for Neurosciences, Vrije Universiteit Brussel, 1090 Brussels, Belgium.)

  • Minghui Wang

    (Cold Spring Harbor Laboratory)

  • Linda Van Aelst

    (Cold Spring Harbor Laboratory)

  • Martin Darvas

    (University of Washington)

  • Luis F. Parada

    (University of Texas Southwestern Medical Center)

  • Richard D. Palmiter

    (University of Washington
    University of Washington)

  • Miao He

    (Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University)

  • Z. Josh Huang

    (Cold Spring Harbor Laboratory)

  • Bo Li

    (Cold Spring Harbor Laboratory)

Abstract

Inhibiting projections from the paraventricular nucleus of the thalamus to a specific division of the amygdala prevents fear conditioning in mice, indicating an important role for the thalamus–amygdala circuit in establishing and maintaining fear responses.

Suggested Citation

  • Mario A. Penzo & Vincent Robert & Jason Tucciarone & Dimitri De Bundel & Minghui Wang & Linda Van Aelst & Martin Darvas & Luis F. Parada & Richard D. Palmiter & Miao He & Z. Josh Huang & Bo Li, 2015. "The paraventricular thalamus controls a central amygdala fear circuit," Nature, Nature, vol. 519(7544), pages 455-459, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7544:d:10.1038_nature13978
    DOI: 10.1038/nature13978
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    Cited by:

    1. Kelsey M. Vollmer & Lisa M. Green & Roger I. Grant & Kion T. Winston & Elizabeth M. Doncheck & Christopher W. Bowen & Jacqueline E. Paniccia & Rachel E. Clarke & Annika Tiller & Preston N. Siegler & B, 2022. "An opioid-gated thalamoaccumbal circuit for the suppression of reward seeking in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Chloe Hegoburu & Yan Tang & Ruifang Niu & Supriya Ghosh & Rodrigo Triana Del Rio & Isabel de Araujo Salgado & Marios Abatis & David Alexandre Mota Caseiro & Erwin H. Burg & Christophe Grundschober & R, 2024. "Social buffering in rats reduces fear by oxytocin triggering sustained changes in central amygdala neuronal activity," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Jun Ma & John J. O’Malley & Malaz Kreiker & Yan Leng & Isbah Khan & Morgan Kindel & Mario A. Penzo, 2024. "Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Jun Wang & Qian Yang & Xue Liu & Jie Li & Ya-Lan Wen & Yuzheng Hu & Tian-Le Xu & Shumin Duan & Han Xu, 2024. "The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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