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Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

Author

Listed:
  • Duane A. Mitchell

    (Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Duke University Medical Center
    Duke University Medical Center)

  • Kristen A. Batich

    (Duke University Medical Center
    Duke University Medical Center)

  • Michael D. Gunn

    (Duke University Medical Center
    Duke University Medical Center)

  • Min-Nung Huang

    (Duke University Medical Center)

  • Luis Sanchez-Perez

    (Duke University Medical Center)

  • Smita K. Nair

    (Duke University Medical Center)

  • Kendra L. Congdon

    (Duke University Medical Center)

  • Elizabeth A. Reap

    (Duke University Medical Center)

  • Gary E. Archer

    (Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Duke University Medical Center)

  • Annick Desjardins

    (Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Duke University Medical Center)

  • Allan H. Friedman

    (Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Duke University Medical Center)

  • Henry S. Friedman

    (Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Duke University Medical Center)

  • James E. Herndon II

    (Duke University Medical Center)

  • April Coan

    (Duke University Medical Center)

  • Roger E. McLendon

    (Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Duke University Medical Center)

  • David A. Reardon

    (Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Duke University Medical Center)

  • James J. Vredenburgh

    (Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Duke University Medical Center)

  • Darell D. Bigner

    (Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Duke University Medical Center
    Duke University Medical Center)

  • John H. Sampson

    (Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Duke University Medical Center
    Duke University Medical Center
    Duke University Medical Center)

Abstract

A clinical trial in patients with glioblastoma shows increased immune and anti-tumour responses to dendritic cell vaccination after pre-conditioning the site of vaccination with tetanus toxoid (Td); similar results are also seen in mice in part due to the actions of the chemokine CCL3, and the findings may represent new ways to improve the efficacy of anti-cancer vaccines.

Suggested Citation

  • Duane A. Mitchell & Kristen A. Batich & Michael D. Gunn & Min-Nung Huang & Luis Sanchez-Perez & Smita K. Nair & Kendra L. Congdon & Elizabeth A. Reap & Gary E. Archer & Annick Desjardins & Allan H. Fr, 2015. "Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients," Nature, Nature, vol. 519(7543), pages 366-369, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7543:d:10.1038_nature14320
    DOI: 10.1038/nature14320
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    Cited by:

    1. Xuan Wang & Yingqi Liu & Chencheng Xue & Yan Hu & Yuanyuan Zhao & Kaiyong Cai & Menghuan Li & Zhong Luo, 2022. "A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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