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Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

Author

Listed:
  • Jonathan R. Brestoff

    (Jill Roberts Institute for Research in IBD, Weill Cornell Medical College, Cornell University
    Perelman School of Medicine, University of Pennsylvania)

  • Brian S. Kim

    (Perelman School of Medicine, University of Pennsylvania
    Present addresses: Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA (B.S.K.); Immunology Research, Biogen Idec, Inc., Cambridge, Massachusetts 02142, USA (S.A.S.).)

  • Steven A. Saenz

    (Perelman School of Medicine, University of Pennsylvania
    Present addresses: Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA (B.S.K.); Immunology Research, Biogen Idec, Inc., Cambridge, Massachusetts 02142, USA (S.A.S.).)

  • Rachel R. Stine

    (Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania)

  • Laurel A. Monticelli

    (Jill Roberts Institute for Research in IBD, Weill Cornell Medical College, Cornell University
    Perelman School of Medicine, University of Pennsylvania)

  • Gregory F. Sonnenberg

    (Jill Roberts Institute for Research in IBD, Weill Cornell Medical College, Cornell University)

  • Joseph J. Thome

    (Columbia Center for Translational Immunology, Columbia University Medical Center
    Columbia University Medical Center)

  • Donna L. Farber

    (Columbia Center for Translational Immunology, Columbia University Medical Center
    Columbia University Medical Center
    Columbia University Medical Center)

  • Kabirullah Lutfy

    (College of Pharmacy, Western University of Health Sciences)

  • Patrick Seale

    (Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania)

  • David Artis

    (Jill Roberts Institute for Research in IBD, Weill Cornell Medical College, Cornell University
    Perelman School of Medicine, University of Pennsylvania)

Abstract

Group 2 innate lymphoid cells are shown to have a critical role in energy homeostasis by producing methionine-enkephalin peptides in response to interleukin 33, thus promoting the beiging of white adipose tissue; increased numbers of beige (also known as brown-like or brite) fat cells in white adipose tissue leads to increased energy expenditure and decreased adiposity.

Suggested Citation

  • Jonathan R. Brestoff & Brian S. Kim & Steven A. Saenz & Rachel R. Stine & Laurel A. Monticelli & Gregory F. Sonnenberg & Joseph J. Thome & Donna L. Farber & Kabirullah Lutfy & Patrick Seale & David Ar, 2015. "Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity," Nature, Nature, vol. 519(7542), pages 242-246, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7542:d:10.1038_nature14115
    DOI: 10.1038/nature14115
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