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Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

Author

Listed:
  • Jie Yin

    (The University of Texas Southwestern Medical Center)

  • Juan Carlos Mobarec

    (Philipps-University Marburg, 35032 Marburg, Germany)

  • Peter Kolb

    (Philipps-University Marburg, 35032 Marburg, Germany)

  • Daniel M. Rosenbaum

    (The University of Texas Southwestern Medical Center)

Abstract

The orexin system regulates sleep and arousal in humans, with orexin receptor antagonists becoming promising therapeutics for insomnia; now, the X-ray crystal structure of the human OX2 receptor in the presence of the insomnia drug suvorexant is solved.

Suggested Citation

  • Jie Yin & Juan Carlos Mobarec & Peter Kolb & Daniel M. Rosenbaum, 2015. "Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant," Nature, Nature, vol. 519(7542), pages 247-250, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7542:d:10.1038_nature14035
    DOI: 10.1038/nature14035
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    Cited by:

    1. Jie Yin & Yanyong Kang & Aaron P. McGrath & Karen Chapman & Megan Sjodt & Eiji Kimura & Atsutoshi Okabe & Tatsuki Koike & Yuhei Miyanohana & Yuji Shimizu & Rameshu Rallabandi & Peng Lian & Xiaochen Ba, 2022. "Molecular mechanism of the wake-promoting agent TAK-925," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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