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Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

Author

Listed:
  • Benjamin D. McNeil

    (Center for Sensory Biology, Johns Hopkins University, School of Medicine)

  • Priyanka Pundir

    (University of Alberta, Edmonton, Alberta T6G 2E1, Canada)

  • Sonya Meeker

    (Johns Hopkins University, School of Medicine)

  • Liang Han

    (Center for Sensory Biology, Johns Hopkins University, School of Medicine)

  • Bradley J. Undem

    (Johns Hopkins University, School of Medicine)

  • Marianna Kulka

    (University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    National Institute for Nanotechnology, National Research Council Canada, Edmonton, Alberta T6G 2M9, Canada)

  • Xinzhong Dong

    (Center for Sensory Biology, Johns Hopkins University, School of Medicine
    Howard Hughes Medical Institute, Johns Hopkins University School of Medicine)

Abstract

Cationic substances, including some drugs, can activate mast cells in an IgE-independent manner, leading to histamine release, inflammation and airway contraction; here, the G-protein-coupled receptor MrgprB2, the orthologue of human MRGPRX2, is shown to be the sole mast cell receptor for these substances in mice.

Suggested Citation

  • Benjamin D. McNeil & Priyanka Pundir & Sonya Meeker & Liang Han & Bradley J. Undem & Marianna Kulka & Xinzhong Dong, 2015. "Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions," Nature, Nature, vol. 519(7542), pages 237-241, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7542:d:10.1038_nature14022
    DOI: 10.1038/nature14022
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