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AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

Author

Listed:
  • Matthew R. Gardner

    (The Scripps Research Institute)

  • Lisa M. Kattenhorn

    (Harvard Medical School, New England Primate Research Center)

  • Hema R. Kondur

    (The Scripps Research Institute)

  • Markus von Schaewen

    (Princeton University)

  • Tatyana Dorfman

    (The Scripps Research Institute)

  • Jessica J. Chiang

    (Harvard Medical School, New England Primate Research Center)

  • Kevin G. Haworth

    (Keck School of Medicine of the University of Southern California)

  • Julie M. Decker

    (Perelman School of Medicine, University of Pennsylvania)

  • Michael D. Alpert

    (Harvard Medical School, New England Primate Research Center
    Immunathon Inc.)

  • Charles C. Bailey

    (The Scripps Research Institute)

  • Ernest S. Neale

    (Harvard Medical School, New England Primate Research Center)

  • Christoph H. Fellinger

    (The Scripps Research Institute)

  • Vinita R. Joshi

    (The Scripps Research Institute)

  • Sebastian P. Fuchs

    (University of Miami Miller School of Medicine)

  • Jose M. Martinez-Navio

    (University of Miami Miller School of Medicine)

  • Brian D. Quinlan

    (The Scripps Research Institute)

  • Annie Y. Yao

    (Harvard Medical School, New England Primate Research Center)

  • Hugo Mouquet

    (Laboratory of Molecular Immunology, The Rockefeller University
    Institut Pasteur)

  • Jason Gorman

    (Vaccine Research Center, National Institutes of Health)

  • Baoshan Zhang

    (Vaccine Research Center, National Institutes of Health)

  • Pascal Poignard

    (IAVI Neutralizing Antibody Center, and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology, The Rockefeller University
    Howard Hughes Medical Institute)

  • Dennis R. Burton

    (IAVI Neutralizing Antibody Center, and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    Ragon Institute of MGH, MIT and Harvard)

  • Peter D. Kwong

    (Vaccine Research Center, National Institutes of Health)

  • Michael Piatak

    (AIDS and Cancer Virus Program, Leidos Biomedical Research, Incorporated, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA)

  • Jeffrey D. Lifson

    (AIDS and Cancer Virus Program, Leidos Biomedical Research, Incorporated, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA)

  • Guangping Gao

    (Gene Therapy Center, University of Massachusetts Medical School)

  • Ronald C. Desrosiers

    (Harvard Medical School, New England Primate Research Center
    University of Miami Miller School of Medicine)

  • David T. Evans

    (University of Wisconsin)

  • Beatrice H. Hahn

    (Perelman School of Medicine, University of Pennsylvania)

  • Alexander Ploss

    (Princeton University)

  • Paula M. Cannon

    (Keck School of Medicine of the University of Southern California)

  • Michael S. Seaman

    (Beth Israel Deaconess Medical Center)

  • Michael Farzan

    (The Scripps Research Institute)

Abstract

The new entry inhibitor eCD4-Ig, consisting of the immunoadhesin form of CD4 (CD4-Ig) fused to a small CCR5-mimetic sulfopeptide, avidly binds two highly conserved sites of the HIV-1 Env protein; the inhibitor has high potency and breadth and can neutralize 100% of a diverse panel of neutralization-resistant HIV-1 viruses, and when delivered to macaques using an adeno-associated virus vector, it can provide effective long-term protection from multiple challenges with simian/human immunodeficiency virus.

Suggested Citation

  • Matthew R. Gardner & Lisa M. Kattenhorn & Hema R. Kondur & Markus von Schaewen & Tatyana Dorfman & Jessica J. Chiang & Kevin G. Haworth & Julie M. Decker & Michael D. Alpert & Charles C. Bailey & Erne, 2015. "AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges," Nature, Nature, vol. 519(7541), pages 87-91, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7541:d:10.1038_nature14264
    DOI: 10.1038/nature14264
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