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Initiation of translation in bacteria by a structured eukaryotic IRES RNA

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  • Timothy M. Colussi

    (University of Colorado Denver School of Medicine
    Howard Hughes Medical Institute, University of Colorado Denver School of Medicine
    Present addresses: Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA (T.M.C.); Cocrystal Discovery, Inc., Mountain View, California 94043, USA (J.Z.); RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA (A.A.K.); Department of Reproductive Medicine, University of California at San Diego, La Jolla California 92093, USA (T.-D.M.P.).)

  • David A. Costantino

    (University of Colorado Denver School of Medicine
    Howard Hughes Medical Institute, University of Colorado Denver School of Medicine)

  • Jianyu Zhu

    (Cell and Developmental Biology, Sinsheimer Labs, University of California at Santa Cruz
    Present addresses: Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA (T.M.C.); Cocrystal Discovery, Inc., Mountain View, California 94043, USA (J.Z.); RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA (A.A.K.); Department of Reproductive Medicine, University of California at San Diego, La Jolla California 92093, USA (T.-D.M.P.).)

  • John Paul Donohue

    (Cell and Developmental Biology, Sinsheimer Labs, University of California at Santa Cruz)

  • Andrei A. Korostelev

    (Cell and Developmental Biology, Sinsheimer Labs, University of California at Santa Cruz
    Present addresses: Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA (T.M.C.); Cocrystal Discovery, Inc., Mountain View, California 94043, USA (J.Z.); RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA (A.A.K.); Department of Reproductive Medicine, University of California at San Diego, La Jolla California 92093, USA (T.-D.M.P.).)

  • Zane A. Jaafar

    (University of Colorado Denver School of Medicine)

  • Terra-Dawn M. Plank

    (University of Colorado Denver School of Medicine
    Present addresses: Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA (T.M.C.); Cocrystal Discovery, Inc., Mountain View, California 94043, USA (J.Z.); RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA (A.A.K.); Department of Reproductive Medicine, University of California at San Diego, La Jolla California 92093, USA (T.-D.M.P.).)

  • Harry F. Noller

    (Cell and Developmental Biology, Sinsheimer Labs, University of California at Santa Cruz)

  • Jeffrey S. Kieft

    (University of Colorado Denver School of Medicine
    Howard Hughes Medical Institute, University of Colorado Denver School of Medicine)

Abstract

A eukaryotic viral internal ribosome entry site (IRES) element is described that binds both bacterial and eukaryotic ribosomes and initiates translation in both, demonstrating that RNA structure-based initiation can occur in both these domains of life, although in bacteria the element uses a mechanism that differs from that in eukaryotes.

Suggested Citation

  • Timothy M. Colussi & David A. Costantino & Jianyu Zhu & John Paul Donohue & Andrei A. Korostelev & Zane A. Jaafar & Terra-Dawn M. Plank & Harry F. Noller & Jeffrey S. Kieft, 2015. "Initiation of translation in bacteria by a structured eukaryotic IRES RNA," Nature, Nature, vol. 519(7541), pages 110-113, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7541:d:10.1038_nature14219
    DOI: 10.1038/nature14219
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    Cited by:

    1. Georg Dorn & Christoph Gmeiner & Tebbe Vries & Emil Dedic & Mihajlo Novakovic & Fred F. Damberger & Christophe Maris & Esteban Finol & Chris P. Sarnowski & Joachim Kohlbrecher & Timothy J. Welsh & Sre, 2023. "Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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