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Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

Author

Listed:
  • Collin Y. Ewald

    (Joslin Diabetes Center, One Joslin Place
    Harvard Stem Cell Institute, 7 Divinity Avenue
    Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02215, USA)

  • Jess N. Landis

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University, 148 Carl Icahn Laboratory, Washington Road, Princeton, New Jersey 08544, USA)

  • Jess Porter Abate

    (Joslin Diabetes Center, One Joslin Place
    Harvard Stem Cell Institute, 7 Divinity Avenue
    Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02215, USA)

  • Coleen T. Murphy

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University, 148 Carl Icahn Laboratory, Washington Road, Princeton, New Jersey 08544, USA)

  • T. Keith Blackwell

    (Joslin Diabetes Center, One Joslin Place
    Harvard Stem Cell Institute, 7 Divinity Avenue
    Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02215, USA)

Abstract

In Caenorhabditis elegans, reduced insulin/IGF-1 signalling can promote longevity through a program that is genetically distinct from the dauer developmental pathway, and requires SKN-1-dependent collagen remodelling that is a broadly essential feature of longevity assurance pathways.

Suggested Citation

  • Collin Y. Ewald & Jess N. Landis & Jess Porter Abate & Coleen T. Murphy & T. Keith Blackwell, 2015. "Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity," Nature, Nature, vol. 519(7541), pages 97-101, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7541:d:10.1038_nature14021
    DOI: 10.1038/nature14021
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    Cited by:

    1. Yan-Ping Zhang & Wen-Hong Zhang & Pan Zhang & Qi Li & Yue Sun & Jia-Wen Wang & Shaobing O. Zhang & Tao Cai & Cheng Zhan & Meng-Qiu Dong, 2022. "Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Zi Wang & Lina Zou & Yiyan Zhang & Mengnan Zhu & Shuxian Zhang & Di Wu & Jianfeng Lan & Xiao Zang & Qi Wang & Hanxin Zhang & Zixing Wu & Huanhu Zhu & Di Chen, 2023. "ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Cyril Statzer & Jin Meng & Richard Venz & Monet Bland & Stacey Robida-Stubbs & Krina Patel & Dunja Petrovic & Raffaella Emsley & Pengpeng Liu & Ianessa Morantte & Cole Haynes & William B. Mair & Alban, 2022. "ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Alina C. Teuscher & Cyril Statzer & Anita Goyala & Seraina A. Domenig & Ingmar Schoen & Max Hess & Alexander M. Hofer & Andrea Fossati & Viola Vogel & Orcun Goksel & Ruedi Aebersold & Collin Y. Ewald, 2024. "Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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