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Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

Author

Listed:
  • Alaji Bah

    (Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Robert M. Vernon

    (Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Zeba Siddiqui

    (Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada)

  • Mickaël Krzeminski

    (Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Ranjith Muhandiram

    (University of Toronto, Toronto, Ontario M5S 1A8, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Charlie Zhao

    (Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada)

  • Nahum Sonenberg

    (McGill University, Montréal, Quebec H3G 1Y6, Canada)

  • Lewis E. Kay

    (Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada
    University of Toronto, Toronto, Ontario M5S 3H6, Canada)

  • Julie D. Forman-Kay

    (Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

Abstract

The structural polymorphism of intrinsically disordered protein 4E-BP2 allows it to regulate translation initiation through post-translational modification-mediated folding, exemplifying a new and potentially general mechanism of biological regulation mediated by intrinsically disordered proteins.

Suggested Citation

  • Alaji Bah & Robert M. Vernon & Zeba Siddiqui & Mickaël Krzeminski & Ranjith Muhandiram & Charlie Zhao & Nahum Sonenberg & Lewis E. Kay & Julie D. Forman-Kay, 2015. "Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch," Nature, Nature, vol. 519(7541), pages 106-109, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7541:d:10.1038_nature13999
    DOI: 10.1038/nature13999
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    Cited by:

    1. Ji Min Lee & Henrik M. Hammarén & Mikhail M. Savitski & Sung Hee Baek, 2023. "Control of protein stability by post-translational modifications," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Changmiao Guo & Raymundo Alfaro-Aco & Chunting Zhang & Ryan W. Russell & Sabine Petry & Tatyana Polenova, 2023. "Structural basis of protein condensation on microtubules underlying branching microtubule nucleation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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