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Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Author

Listed:
  • Elisa Gomez Perdiguero

    (Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK)

  • Kay Klapproth

    (German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany)

  • Christian Schulz

    (Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK)

  • Katrin Busch

    (German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany)

  • Emanuele Azzoni

    (MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital University of Oxford, Oxford OX3 9DS, UK)

  • Lucile Crozet

    (Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK)

  • Hannah Garner

    (Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK)

  • Celine Trouillet

    (Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK)

  • Marella F. de Bruijn

    (MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital University of Oxford, Oxford OX3 9DS, UK)

  • Frederic Geissmann

    (Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK)

  • Hans-Reimer Rodewald

    (German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany)

Abstract

To determine the origin of adult tissue-resident macrophages, a mouse lineage tracing study has revealed that these cells derive from erythro-myeloid progenitors in the yolk sac that are distinct from fetal and adult haematopoietic stem cells.

Suggested Citation

  • Elisa Gomez Perdiguero & Kay Klapproth & Christian Schulz & Katrin Busch & Emanuele Azzoni & Lucile Crozet & Hannah Garner & Celine Trouillet & Marella F. de Bruijn & Frederic Geissmann & Hans-Reimer , 2015. "Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors," Nature, Nature, vol. 518(7540), pages 547-551, February.
    • Handle: RePEc:nat:nature:v:518:y:2015:i:7540:d:10.1038_nature13989
    DOI: 10.1038/nature13989
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    Cited by:

    1. Qizhou Lian & Kui Zhang & Zhao Zhang & Fuyu Duan & Liyan Guo & Weiren Luo & Bobo Wing-Yee Mok & Abhimanyu Thakur & Xiaoshan Ke & Pedram Motallebnejad & Vlad Nicolaescu & Jonathan Chen & Chui Yan Ma & , 2022. "Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. C. Biben & T. S. Weber & K. S. Potts & J. Choi & D. C. Miles & A. Carmagnac & T. Sargeant & C. A. Graaf & K. A. Fennell & A. Farley & O. J. Stonehouse & M. A. Dawson & D. J. Hilton & S. H. Naik & S. T, 2023. "In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Miki Nagase & Hidetake Kurihara & Atsu Aiba & Morag J Young & Tatsuo Sakai, 2016. "Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-17, March.
    4. Jake R. Thomas & Anna Appios & Emily F. Calderbank & Nagisa Yoshida & Xiaohui Zhao & Russell S. Hamilton & Ashley Moffett & Andrew Sharkey & Elisa Laurenti & Courtney W. Hanna & Naomi McGovern, 2023. "Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Steven Schepanski & Mattia Chini & Veronika Sternemann & Christopher Urbschat & Kristin Thiele & Ting Sun & Yu Zhao & Mareike Poburski & Anna Woestemeier & Marie-Theres Thieme & Dimitra E. Zazara & Ma, 2022. "Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    6. Liang Yong & Yafen Yu & Bao Li & Huiyao Ge & Qi Zhen & Yiwen Mao & Yanxia Yu & Lu Cao & Ruixue Zhang & Zhuo Li & Yirui Wang & Wencheng Fan & Chang Zhang & Daiyue Wang & Sihan Luo & Yuanming Bai & Shir, 2022. "Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. Anna E. Williamson & Sanuri Liyanage & Mohammadhossein Hassanshahi & Malathi S. I. Dona & Deborah Toledo-Flores & Dang X. A. Tran & Catherine Dimasi & Nisha Schwarz & Sanuja Fernando & Thalia Salagara, 2024. "Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    8. Lauriane Galle-Treger & Doumet Georges Helou & Christine Quach & Emily Howard & Benjamin P. Hurrell & German R. Aleman Muench & Pedram Shafiei-Jahani & Jacob D. Painter & Andrea Iorga & Lily Dara & Ju, 2022. "Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    9. Seiji Taniguchi & Takahiro Matsui & Kenji Kimura & Soichiro Funaki & Yu Miyamoto & Yutaka Uchida & Takao Sudo & Junichi Kikuta & Tetsuya Hara & Daisuke Motooka & Yu-Chen Liu & Daisuke Okuzaki & Eiichi, 2023. "In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    10. Nourhan Abdelfattah & Parveen Kumar & Caiyi Wang & Jia-Shiun Leu & William F. Flynn & Ruli Gao & David S. Baskin & Kumar Pichumani & Omkar B. Ijare & Stephanie L. Wood & Suzanne Z. Powell & David L. H, 2022. "Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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