IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v518y2015i7539d10.1038_nature14252.html
   My bibliography  Save this article

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

Author

Listed:
  • Elizabeta Gjoneska

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Broad Institute of Harvard University and Massachusetts Institute of Technology)

  • Andreas R. Pfenning

    (Broad Institute of Harvard University and Massachusetts Institute of Technology
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology)

  • Hansruedi Mathys

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Gerald Quon

    (Broad Institute of Harvard University and Massachusetts Institute of Technology
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology)

  • Anshul Kundaje

    (Broad Institute of Harvard University and Massachusetts Institute of Technology
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology
    Stanford University)

  • Li-Huei Tsai

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Broad Institute of Harvard University and Massachusetts Institute of Technology)

  • Manolis Kellis

    (Broad Institute of Harvard University and Massachusetts Institute of Technology
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology)

Abstract

Analysis of transcriptional and epigenomic changes in the hippocampus of a mouse model of Alzheimer’s disease shows that immune function genes and regulatory regions are upregulated, whereas genes and regulatory regions involved in synaptic plasticity, learning and memory are downregulated; genetic variants associated with Alzheimer’s disease are only enriched in orthologues of upregulated immune regions, suggesting that dysregulation of immune processes may underlie Alzheimer’s disease predisposition.

Suggested Citation

  • Elizabeta Gjoneska & Andreas R. Pfenning & Hansruedi Mathys & Gerald Quon & Anshul Kundaje & Li-Huei Tsai & Manolis Kellis, 2015. "Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease," Nature, Nature, vol. 518(7539), pages 365-369, February.
    • Handle: RePEc:nat:nature:v:518:y:2015:i:7539:d:10.1038_nature14252
    DOI: 10.1038/nature14252
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature14252
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature14252?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Byungwook Kim & Luke Child Dabin & Mason Douglas Tate & Hande Karahan & Ahmad Daniel Sharify & Dominic J. Acri & Md Mamun Al-Amin & Stéphanie Philtjens & Daniel Curtis Smith & H. R. Sagara Wijeratne &, 2024. "Effects of SPI1-mediated transcriptome remodeling on Alzheimer’s disease-related phenotypes in mouse models of Aβ amyloidosis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Liang-Yu Fu & Tao Zhu & Xinkai Zhou & Ranran Yu & Zhaohui He & Peijing Zhang & Zhigui Wu & Ming Chen & Kerstin Kaufmann & Dijun Chen, 2022. "ChIP-Hub provides an integrative platform for exploring plant regulome," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:518:y:2015:i:7539:d:10.1038_nature14252. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.