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Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

Author

Listed:
  • Sascha Rutz

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Nobuhiko Kayagaki

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Qui T. Phung

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Celine Eidenschenk

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Rajkumar Noubade

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Xiaoting Wang

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Justin Lesch

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Rongze Lu

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Kim Newton

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Oscar W. Huang

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Andrea G. Cochran

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Mark Vasser

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Benjamin P. Fauber

    (Discovery Chemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Jason DeVoss

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Joshua Webster

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Lauri Diehl

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Zora Modrusan

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Donald S. Kirkpatrick

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Jennie R. Lill

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Wenjun Ouyang

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

  • Vishva M. Dixit

    (Genentech, 1 DNA Way, South San Francisco, California 94080, USA)

Abstract

The deubiquitinase enzyme DUBA is shown to act as a negative regulator of interleukin-17A (IL-17A) in TH17 cells; DUBA interacts with and stabilizes the ubiquitin ligase UBR5, which in turn targets RORγt for degradation in the proteaseome, thus limiting IL-17A production.

Suggested Citation

  • Sascha Rutz & Nobuhiko Kayagaki & Qui T. Phung & Celine Eidenschenk & Rajkumar Noubade & Xiaoting Wang & Justin Lesch & Rongze Lu & Kim Newton & Oscar W. Huang & Andrea G. Cochran & Mark Vasser & Benj, 2015. "Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells," Nature, Nature, vol. 518(7539), pages 417-421, February.
    • Handle: RePEc:nat:nature:v:518:y:2015:i:7539:d:10.1038_nature13979
    DOI: 10.1038/nature13979
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    Cited by:

    1. Duomeng Yang & Tingting Geng & Andrew G. Harrison & Jason G. Cahoon & Jian Xing & Baihai Jiao & Mark Wang & Chao Cheng & Robert E. Hill & Huadong Wang & Anthony T. Vella & Gong Cheng & Yanlin Wang & P, 2024. "UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Li-Kai Chu & Xu Cao & Lin Wan & Qiang Diao & Yu Zhu & Yu Kan & Li-Li Ye & Yi-Ming Mao & Xing-Qiang Dong & Qian-Wei Xiong & Ming-Cui Fu & Ting Zhang & Hui-Ting Zhou & Shi-Zhong Cai & Zhou-Rui Ma & Ssu-, 2023. "Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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