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Apico-basal forces exerted by apoptotic cells drive epithelium folding

Author

Listed:
  • Bruno Monier

    (Université de Toulouse, UPS, LBCMCP, F-31062 Toulouse, France
    CNRS, LBCMCP, F-31062 Toulouse, France)

  • Melanie Gettings

    (Université de Toulouse, UPS, LBCMCP, F-31062 Toulouse, France
    CNRS, LBCMCP, F-31062 Toulouse, France)

  • Guillaume Gay

    (DamCB, Data Analysis and Modelling for Cell Biology, 13005 Marseille, France)

  • Thomas Mangeat

    (Université de Toulouse, UPS, LBCMCP, F-31062 Toulouse, France
    CNRS, LBCMCP, F-31062 Toulouse, France)

  • Sonia Schott

    (Université de Toulouse, UPS, LBCMCP, F-31062 Toulouse, France
    CNRS, LBCMCP, F-31062 Toulouse, France)

  • Ana Guarner

    (Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Nicolás Cabrera 1, Cantoblanco, 28049 Madrid, Spain)

  • Magali Suzanne

    (Université de Toulouse, UPS, LBCMCP, F-31062 Toulouse, France
    CNRS, LBCMCP, F-31062 Toulouse, France)

Abstract

Apoptotic cell death is required for morphogenesis of the developing leg joint of fruitflies; using this model system, the authors show here that within apoptotic cells a transient pulling force exerted through a highly dynamic apico-basal myosin II cable-like structure acts as a mechanical signal to increase tissue tension and modify tissue shape.

Suggested Citation

  • Bruno Monier & Melanie Gettings & Guillaume Gay & Thomas Mangeat & Sonia Schott & Ana Guarner & Magali Suzanne, 2015. "Apico-basal forces exerted by apoptotic cells drive epithelium folding," Nature, Nature, vol. 518(7538), pages 245-248, February.
    • Handle: RePEc:nat:nature:v:518:y:2015:i:7538:d:10.1038_nature14152
    DOI: 10.1038/nature14152
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    Cited by:

    1. Aurélien Villedieu & Lale Alpar & Isabelle Gaugué & Amina Joudat & François Graner & Floris Bosveld & Yohanns Bellaïche, 2023. "Homeotic compartment curvature and tension control spatiotemporal folding dynamics," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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