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RNA helicase DDX21 coordinates transcription and ribosomal RNA processing

Author

Listed:
  • Eliezer Calo

    (Stanford University School of Medicine)

  • Ryan A. Flynn

    (Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine)

  • Lance Martin

    (Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine)

  • Robert C. Spitale

    (Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine)

  • Howard Y. Chang

    (Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine)

  • Joanna Wysocka

    (Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

DEAD-box RNA helicase DDX21 is involved in both the transcription and RNA processing of ribosomal genes in human cells, sensing the transcriptional status of both RNA polymerase I and RNA polymerase II and associating with non-coding RNAs involved in ribonucleoprotein formation, possibly allowing for coordinated regulation of protein synthesis.

Suggested Citation

  • Eliezer Calo & Ryan A. Flynn & Lance Martin & Robert C. Spitale & Howard Y. Chang & Joanna Wysocka, 2015. "RNA helicase DDX21 coordinates transcription and ribosomal RNA processing," Nature, Nature, vol. 518(7538), pages 249-253, February.
    • Handle: RePEc:nat:nature:v:518:y:2015:i:7538:d:10.1038_nature13923
    DOI: 10.1038/nature13923
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    Cited by:

    1. Xiuqin Wang & Gongcheng Hu & Lisha Wang & Yuli Lu & Yanjiang Liu & Shengxiong Yang & Junzhi Liao & Qian Zhao & Qiuling Huang & Wentao Wang & Wenjing Guo & Heying Li & Yu Fu & Yawei Song & Qingqing Cai, 2024. "DEAD-box RNA helicase 10 is required for 18S rRNA maturation by controlling the release of U3 snoRNA from pre-rRNA in embryonic stem cells," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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