IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v518y2015i7537d10.1038_nature13905.html
   My bibliography  Save this article

MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

Author

Listed:
  • Christopher J. Cheng

    (Cellular and Developmental Biology, Yale University
    Yale University
    Yale University
    Present addresses: Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410, USA (C.J.C.); OrbiMed Advisors LLC, 601 Lexington Avenue, 54th Floor, New York, New York 10022, USA (I.A.B.); Departments of Developmental Biology and Genetics, Washington University, St. Louis, Missouri 63110, USA (Z.P.); Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee–Knoxville, Knoxville, Tennessee 37996, USA (F.B.); Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA (F.J.S.).)

  • Raman Bahal

    (Yale University)

  • Imran A. Babar

    (Cellular and Developmental Biology, Yale University
    Present addresses: Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410, USA (C.J.C.); OrbiMed Advisors LLC, 601 Lexington Avenue, 54th Floor, New York, New York 10022, USA (I.A.B.); Departments of Developmental Biology and Genetics, Washington University, St. Louis, Missouri 63110, USA (Z.P.); Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee–Knoxville, Knoxville, Tennessee 37996, USA (F.B.); Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA (F.J.S.).)

  • Zachary Pincus

    (Cellular and Developmental Biology, Yale University
    Present addresses: Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410, USA (C.J.C.); OrbiMed Advisors LLC, 601 Lexington Avenue, 54th Floor, New York, New York 10022, USA (I.A.B.); Departments of Developmental Biology and Genetics, Washington University, St. Louis, Missouri 63110, USA (Z.P.); Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee–Knoxville, Knoxville, Tennessee 37996, USA (F.B.); Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA (F.J.S.).)

  • Francisco Barrera

    (Yale University
    Present addresses: Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410, USA (C.J.C.); OrbiMed Advisors LLC, 601 Lexington Avenue, 54th Floor, New York, New York 10022, USA (I.A.B.); Departments of Developmental Biology and Genetics, Washington University, St. Louis, Missouri 63110, USA (Z.P.); Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee–Knoxville, Knoxville, Tennessee 37996, USA (F.B.); Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA (F.J.S.).)

  • Connie Liu

    (Cellular and Developmental Biology, Yale University)

  • Alexander Svoronos

    (Yale University)

  • Demetrios T. Braddock

    (Yale University)

  • Peter M. Glazer

    (Yale University)

  • Donald M. Engelman

    (Yale University)

  • W. Mark Saltzman

    (Yale University)

  • Frank J. Slack

    (Cellular and Developmental Biology, Yale University
    Present addresses: Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410, USA (C.J.C.); OrbiMed Advisors LLC, 601 Lexington Avenue, 54th Floor, New York, New York 10022, USA (I.A.B.); Departments of Developmental Biology and Genetics, Washington University, St. Louis, Missouri 63110, USA (Z.P.); Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee–Knoxville, Knoxville, Tennessee 37996, USA (F.B.); Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA (F.J.S.).)

Abstract

A novel anti-microRNA delivery platform that targets the acidic tumour microenvironment, in which a chosen anti-miRNA is coupled to a peptide that can transport the anti-miRNA across cell membranes specifically in an acidic environment.

Suggested Citation

  • Christopher J. Cheng & Raman Bahal & Imran A. Babar & Zachary Pincus & Francisco Barrera & Connie Liu & Alexander Svoronos & Demetrios T. Braddock & Peter M. Glazer & Donald M. Engelman & W. Mark Salt, 2015. "MicroRNA silencing for cancer therapy targeted to the tumour microenvironment," Nature, Nature, vol. 518(7537), pages 107-110, February.
  • Handle: RePEc:nat:nature:v:518:y:2015:i:7537:d:10.1038_nature13905
    DOI: 10.1038/nature13905
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13905
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature13905?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:518:y:2015:i:7537:d:10.1038_nature13905. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.