Author
Listed:
- Christopher J. Cheng
(Cellular and Developmental Biology, Yale University
Yale University
Yale University
Present addresses: Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410, USA (C.J.C.); OrbiMed Advisors LLC, 601 Lexington Avenue, 54th Floor, New York, New York 10022, USA (I.A.B.); Departments of Developmental Biology and Genetics, Washington University, St. Louis, Missouri 63110, USA (Z.P.); Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee–Knoxville, Knoxville, Tennessee 37996, USA (F.B.); Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA (F.J.S.).)
- Raman Bahal
(Yale University)
- Imran A. Babar
(Cellular and Developmental Biology, Yale University
Present addresses: Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410, USA (C.J.C.); OrbiMed Advisors LLC, 601 Lexington Avenue, 54th Floor, New York, New York 10022, USA (I.A.B.); Departments of Developmental Biology and Genetics, Washington University, St. Louis, Missouri 63110, USA (Z.P.); Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee–Knoxville, Knoxville, Tennessee 37996, USA (F.B.); Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA (F.J.S.).)
- Zachary Pincus
(Cellular and Developmental Biology, Yale University
Present addresses: Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410, USA (C.J.C.); OrbiMed Advisors LLC, 601 Lexington Avenue, 54th Floor, New York, New York 10022, USA (I.A.B.); Departments of Developmental Biology and Genetics, Washington University, St. Louis, Missouri 63110, USA (Z.P.); Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee–Knoxville, Knoxville, Tennessee 37996, USA (F.B.); Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA (F.J.S.).)
- Francisco Barrera
(Yale University
Present addresses: Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410, USA (C.J.C.); OrbiMed Advisors LLC, 601 Lexington Avenue, 54th Floor, New York, New York 10022, USA (I.A.B.); Departments of Developmental Biology and Genetics, Washington University, St. Louis, Missouri 63110, USA (Z.P.); Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee–Knoxville, Knoxville, Tennessee 37996, USA (F.B.); Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA (F.J.S.).)
- Connie Liu
(Cellular and Developmental Biology, Yale University)
- Alexander Svoronos
(Yale University)
- Demetrios T. Braddock
(Yale University)
- Peter M. Glazer
(Yale University)
- Donald M. Engelman
(Yale University)
- W. Mark Saltzman
(Yale University)
- Frank J. Slack
(Cellular and Developmental Biology, Yale University
Present addresses: Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410, USA (C.J.C.); OrbiMed Advisors LLC, 601 Lexington Avenue, 54th Floor, New York, New York 10022, USA (I.A.B.); Departments of Developmental Biology and Genetics, Washington University, St. Louis, Missouri 63110, USA (Z.P.); Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee–Knoxville, Knoxville, Tennessee 37996, USA (F.B.); Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA (F.J.S.).)
Abstract
A novel anti-microRNA delivery platform that targets the acidic tumour microenvironment, in which a chosen anti-miRNA is coupled to a peptide that can transport the anti-miRNA across cell membranes specifically in an acidic environment.
Suggested Citation
Christopher J. Cheng & Raman Bahal & Imran A. Babar & Zachary Pincus & Francisco Barrera & Connie Liu & Alexander Svoronos & Demetrios T. Braddock & Peter M. Glazer & Donald M. Engelman & W. Mark Salt, 2015.
"MicroRNA silencing for cancer therapy targeted to the tumour microenvironment,"
Nature, Nature, vol. 518(7537), pages 107-110, February.
Handle:
RePEc:nat:nature:v:518:y:2015:i:7537:d:10.1038_nature13905
DOI: 10.1038/nature13905
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