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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

Author

Listed:
  • Bret D. Freudenthal

    (Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA)

  • William A. Beard

    (Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA)

  • Lalith Perera

    (Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA)

  • David D. Shock

    (Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA)

  • Taejin Kim

    (New York University, and NYU-ECNU Center for Computational Chemistry at NYU Shanghai, 10th Floor Silver Center, 100 Washington Square East, New York, New York 10003, USA
    Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, New York 10012, USA)

  • Tamar Schlick

    (New York University, and NYU-ECNU Center for Computational Chemistry at NYU Shanghai, 10th Floor Silver Center, 100 Washington Square East, New York, New York 10003, USA
    Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, New York 10012, USA)

  • Samuel H. Wilson

    (Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA)

Abstract

Time--β bound to substrate DNA as it inserts 8-oxo-dGTP opposite either cytosine or adenine.

Suggested Citation

  • Bret D. Freudenthal & William A. Beard & Lalith Perera & David D. Shock & Taejin Kim & Tamar Schlick & Samuel H. Wilson, 2015. "Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide," Nature, Nature, vol. 517(7536), pages 635-639, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7536:d:10.1038_nature13886
    DOI: 10.1038/nature13886
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    Citations

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    Cited by:

    1. Joonas A. Jamsen & David D. Shock & Samuel H. Wilson, 2022. "Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Caleb Chang & Christie Lee Luo & Yang Gao, 2022. "In crystallo observation of three metal ion promoted DNA polymerase misincorporation," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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