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Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis

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  • Henri-François Renard

    (Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    CNRS UMR3666, 75005 Paris, France
    U1143 INSERM, 75005 Paris, France)

  • Mijo Simunovic

    (Institut Curie — Centre de Recherche, Membrane and Cell Functions group, CNRS UMR 168, Physico-Chimie Curie, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    The University of Chicago, 5735 S Ellis Ave, Chicago, Ilinois 60637, USA)

  • Joël Lemière

    (Institut Curie — Centre de Recherche, Biomimetism of Cell Movement group, CNRS UMR 168, Physico-Chimie Curie, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France)

  • Emmanuel Boucrot

    (Institute of Structural and Molecular Biology, University College London & Birkbeck College, London WC1E 6BT, UK)

  • Maria Daniela Garcia-Castillo

    (Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    CNRS UMR3666, 75005 Paris, France
    U1143 INSERM, 75005 Paris, France)

  • Senthil Arumugam

    (Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    CNRS UMR3666, 75005 Paris, France
    U1143 INSERM, 75005 Paris, France)

  • Valérie Chambon

    (Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    CNRS UMR3666, 75005 Paris, France
    U1143 INSERM, 75005 Paris, France)

  • Christophe Lamaze

    (CNRS UMR3666, 75005 Paris, France
    U1143 INSERM, 75005 Paris, France
    Institut Curie — Centre de Recherche, Membrane Dynamics and Mechanics of Intracellular Signaling group, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • Christian Wunder

    (Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    CNRS UMR3666, 75005 Paris, France
    U1143 INSERM, 75005 Paris, France)

  • Anne K. Kenworthy

    (Vanderbilt School of Medicine, 718 Light Hall, Nashville, Tennessee 37232, USA)

  • Anne A. Schmidt

    (CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, 15 rue Hélène Brion, 75205 Paris Cedex 13, France)

  • Harvey T. McMahon

    (Medical Research Council, Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK)

  • Cécile Sykes

    (Institut Curie — Centre de Recherche, Biomimetism of Cell Movement group, CNRS UMR 168, Physico-Chimie Curie, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • Patricia Bassereau

    (Institut Curie — Centre de Recherche, Membrane and Cell Functions group, CNRS UMR 168, Physico-Chimie Curie, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • Ludger Johannes

    (Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    CNRS UMR3666, 75005 Paris, France
    U1143 INSERM, 75005 Paris, France)

Abstract

Endophilin-A2 (endoA2) is shown to mediate clathrin-independent endocytosis of Shiga and cholera toxins, and to function in parallel with dynamin and actin in the pulling-force-driven scission of Shiga-toxin-induced tubular structures.

Suggested Citation

  • Henri-François Renard & Mijo Simunovic & Joël Lemière & Emmanuel Boucrot & Maria Daniela Garcia-Castillo & Senthil Arumugam & Valérie Chambon & Christophe Lamaze & Christian Wunder & Anne K. Kenworthy, 2015. "Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis," Nature, Nature, vol. 517(7535), pages 493-496, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7535:d:10.1038_nature14064
    DOI: 10.1038/nature14064
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    Cited by:

    1. Raluca Groza & Kita Valerie Schmidt & Paul Markus Müller & Paolo Ronchi & Claire Schlack-Leigers & Ursula Neu & Dmytro Puchkov & Rumiana Dimova & Claudia Matthaeus & Justin Taraska & Thomas R. Weikl &, 2024. "Adhesion energy controls lipid binding-mediated endocytosis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Anabel-Lise Le Roux & Caterina Tozzi & Nikhil Walani & Xarxa Quiroga & Dobryna Zalvidea & Xavier Trepat & Margarita Staykova & Marino Arroyo & Pere Roca-Cusachs, 2021. "Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Samsuzzoha Mondal & Karthik Narayan & Samuel Botterbusch & Imania Powers & Jason Zheng & Honey Priya James & Rui Jin & Tobias Baumgart, 2022. "Multivalent interactions between molecular components involved in fast endophilin mediated endocytosis drive protein phase separation," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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