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The mutational landscapes of genetic and chemical models of Kras-driven lung cancer

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Listed:
  • Peter M. K. Westcott

    (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
    University of California San Francisco)

  • Kyle D. Halliwill

    (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
    University of California San Francisco)

  • Minh D. To

    (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco)

  • Mamunur Rashid

    (Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK)

  • Alistair G. Rust

    (Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK)

  • Thomas M. Keane

    (Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK)

  • Reyno Delrosario

    (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco)

  • Kuang-Yu Jen

    (University of California San Francisco)

  • Kay E. Gurley

    (Fred Hutchinson Cancer Research Center)

  • Christopher J. Kemp

    (Fred Hutchinson Cancer Research Center)

  • Erik Fredlund

    (Science for Life Laboratory, Karolinska Institute, Stockholm 171 21, Sweden)

  • David A. Quigley

    (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco)

  • David J. Adams

    (Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK)

  • Allan Balmain

    (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
    University of California San Francisco)

Abstract

Whole-exome sequencing is used to compare the mutational landscape of adenomas from three mouse models of non-small-cell lung cancer, induced either by exposure to carcinogens or by genetic mutation of Kras; the results reveal that the two types of tumour have different mutational profiles and adopt different routes to tumour development.

Suggested Citation

  • Peter M. K. Westcott & Kyle D. Halliwill & Minh D. To & Mamunur Rashid & Alistair G. Rust & Thomas M. Keane & Reyno Delrosario & Kuang-Yu Jen & Kay E. Gurley & Christopher J. Kemp & Erik Fredlund & Da, 2015. "The mutational landscapes of genetic and chemical models of Kras-driven lung cancer," Nature, Nature, vol. 517(7535), pages 489-492, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7535:d:10.1038_nature13898
    DOI: 10.1038/nature13898
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