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IgG1 protects against renal disease in a mouse model of cryoglobulinaemia

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Listed:
  • Richard T. Strait

    (Cincinnati Children’s Hospital Medical Center
    University of Cincinnati College of Medicine)

  • Monica T. Posgai

    (Biochemistry and Microbiology, University of Cincinnati College of Medicine)

  • Ashley Mahler

    (Cincinnati Children’s Hospital Medical Center)

  • Nathaniel Barasa

    (Cincinnati Children’s Hospital Medical Center)

  • Chaim O. Jacob

    (University of Southern California School of Medicine)

  • Jörg Köhl

    (Cincinnati Children’s Hospital Medical Center
    Institute for Systemic Inflammation Research, University of Lübeck, 23538 Lübeck, Germany)

  • Marc Ehlers

    (Institute for Systemic Inflammation Research, University of Lübeck, 23538 Lübeck, Germany)

  • Keith Stringer

    (Cincinnati Children’s Hospital Medical Center)

  • Shiva Kumar Shanmukhappa

    (Cincinnati Children’s Hospital Medical Center)

  • David Witte

    (Cincinnati Children’s Hospital Medical Center)

  • Md Monir Hossain

    (Cincinnati Children’s Hospital Medical Center)

  • Marat Khodoun

    (Allergy and Rheumatology, University of Cincinnati College of Medicine)

  • Andrew B. Herr

    (Biochemistry and Microbiology, University of Cincinnati College of Medicine
    Cincinnati Children’s Hospital Medical Center)

  • Fred D. Finkelman

    (Cincinnati Children’s Hospital Medical Center
    Allergy and Rheumatology, University of Cincinnati College of Medicine
    Medical Service, Cincinnati Veterans Affairs Medical Center)

Abstract

Here, the predominant murine immunoglobulin G subclass, IgG1, which is a poor activator of effector mechanisms, is shown to have a regulatory function, protecting against the development of IgG3 immune-complex-driven renal disease by competing with IgG3 for antigen and increasing immune complex solubility.

Suggested Citation

  • Richard T. Strait & Monica T. Posgai & Ashley Mahler & Nathaniel Barasa & Chaim O. Jacob & Jörg Köhl & Marc Ehlers & Keith Stringer & Shiva Kumar Shanmukhappa & David Witte & Md Monir Hossain & Marat , 2015. "IgG1 protects against renal disease in a mouse model of cryoglobulinaemia," Nature, Nature, vol. 517(7535), pages 501-504, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7535:d:10.1038_nature13868
    DOI: 10.1038/nature13868
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