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Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Author

Listed:
  • Kai Deng

    (Johns Hopkins University School of Medicine)

  • Mihaela Pertea

    (Johns Hopkins University School of Medicine
    Center for Computational Biology, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine)

  • Anthony Rongvaux

    (Yale University School of Medicine)

  • Leyao Wang

    (Yale School of Public Health)

  • Christine M. Durand

    (Johns Hopkins University School of Medicine)

  • Gabriel Ghiaur

    (Johns Hopkins University School of Medicine)

  • Jun Lai

    (Johns Hopkins University School of Medicine)

  • Holly L. McHugh

    (Johns Hopkins University School of Medicine)

  • Haiping Hao

    (Deep Sequencing and Microarray Core, Johns Hopkins University School of Medicine)

  • Hao Zhang

    (Johns Hopkins Bloomberg School of Public Health)

  • Joseph B. Margolick

    (Johns Hopkins Bloomberg School of Public Health)

  • Cagan Gurer

    (Regeneron Pharmaceuticals Inc.)

  • Andrew J. Murphy

    (Regeneron Pharmaceuticals Inc.)

  • David M. Valenzuela

    (Regeneron Pharmaceuticals Inc.)

  • George D. Yancopoulos

    (Regeneron Pharmaceuticals Inc.)

  • Steven G. Deeks

    (University of California, San Francisco, San Francisco, California 94110, USA)

  • Till Strowig

    (Yale University School of Medicine)

  • Priti Kumar

    (Yale University School of Medicine)

  • Janet D. Siliciano

    (Johns Hopkins University School of Medicine)

  • Steven L. Salzberg

    (Center for Computational Biology, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Richard A. Flavell

    (Yale University School of Medicine
    Howard Hughes Medical Institute)

  • Liang Shan

    (Yale University School of Medicine)

  • Robert F. Siliciano

    (Johns Hopkins University School of Medicine
    Howard Hughes Medical Institute)

Abstract

Despite receiving antiretroviral therapy, most patients with HIV still have latent reservoirs of the virus; here, these reservoirs are shown to be dominated by viruses with cytotoxic T lymphocyte escape mutations, with potential implications for the development of therapeutic vaccines.

Suggested Citation

  • Kai Deng & Mihaela Pertea & Anthony Rongvaux & Leyao Wang & Christine M. Durand & Gabriel Ghiaur & Jun Lai & Holly L. McHugh & Haiping Hao & Hao Zhang & Joseph B. Margolick & Cagan Gurer & Andrew J. M, 2015. "Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations," Nature, Nature, vol. 517(7534), pages 381-385, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7534:d:10.1038_nature14053
    DOI: 10.1038/nature14053
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    Cited by:

    1. Jessica M Conway & Alan S Perelson & Jonathan Z Li, 2019. "Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers," PLOS Computational Biology, Public Library of Science, vol. 15(7), pages 1-26, July.
    2. Elham Khatamzas & Markus H. Antwerpen & Alexandra Rehn & Alexander Graf & Johannes Christian Hellmuth & Alexandra Hollaus & Anne-Wiebe Mohr & Erik Gaitzsch & Tobias Weiglein & Enrico Georgi & Clemens , 2022. "Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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