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An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

Author

Listed:
  • Alexander S. Banks

    (Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School)

  • Fiona E. McAllister

    (Harvard Medical School)

  • João Paulo G. Camporez

    (Yale University School of Medicine)

  • Peter-James H. Zushin

    (Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School)

  • Michael J. Jurczak

    (Yale University School of Medicine)

  • Dina Laznik-Bogoslavski

    (Dana-Farber Cancer Institute)

  • Gerald I. Shulman

    (Yale University School of Medicine)

  • Steven P. Gygi

    (Harvard Medical School)

  • Bruce M. Spiegelman

    (Harvard Medical School
    Dana-Farber Cancer Institute)

Abstract

Blocking ERK/MAP kinases improves insulin sensitivity thorough a mechanism similar to the actions of the anti-diabetic thiazolidinediones drugs on PPARγ.

Suggested Citation

  • Alexander S. Banks & Fiona E. McAllister & João Paulo G. Camporez & Peter-James H. Zushin & Michael J. Jurczak & Dina Laznik-Bogoslavski & Gerald I. Shulman & Steven P. Gygi & Bruce M. Spiegelman, 2015. "An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ," Nature, Nature, vol. 517(7534), pages 391-395, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7534:d:10.1038_nature13887
    DOI: 10.1038/nature13887
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