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CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

Author

Listed:
  • Yu-Hwa Huang

    (Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA)

  • Chen Zhu

    (Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Yasuyuki Kondo

    (Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA)

  • Ana C. Anderson

    (Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Amit Gandhi

    (Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA)

  • Andrew Russell

    (Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA)

  • Stephanie K. Dougan

    (Whitehead Institute, Massachusetts Institute of Technology)

  • Britt-Sabina Petersen

    (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel 24105, Germany)

  • Espen Melum

    (Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Norwegian PSC Research Center, Surgery and Transplantation, Oslo University Hospital, Oslo 0424, Norway)

  • Thomas Pertel

    (Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Kiera L. Clayton

    (University of Toronto, Toronto, Ontario M5S1A8, Canada)

  • Monika Raab

    (Cell Signalling Section, University of Cambridge, Cambridge CB2 1QP, UK)

  • Qiang Chen

    (State Key Laboratory of Biotherapy, West China Hospital, Sichuan University)

  • Nicole Beauchemin

    (Goodman Cancer Research Centre, McGill University, Montreal H3G 1Y6, Canada)

  • Paul J. Yazaki

    (Beckman Institute, City of Hope)

  • Michal Pyzik

    (Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA)

  • Mario A. Ostrowski

    (University of Toronto, Toronto, Ontario M5S1A8, Canada
    Keenan Research Centre of St. Michael’s Hospital, Toronto, Ontario M5S1A8, Canada)

  • Jonathan N. Glickman

    (GI Pathology, Miraca Life Sciences)

  • Christopher E. Rudd

    (Cell Signalling Section, University of Cambridge, Cambridge CB2 1QP, UK)

  • Hidde L. Ploegh

    (Whitehead Institute, Massachusetts Institute of Technology)

  • Andre Franke

    (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel 24105, Germany)

  • Gregory A. Petsko

    (Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA)

  • Vijay K. Kuchroo

    (Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Richard S. Blumberg

    (Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA)

Abstract

CEACAM1 functions as a novel heterophilic ligand for TIM-3 and is necessary for TIM-3-mediated tolerance, which has marked consequences for inflammation, infection and cancer.

Suggested Citation

  • Yu-Hwa Huang & Chen Zhu & Yasuyuki Kondo & Ana C. Anderson & Amit Gandhi & Andrew Russell & Stephanie K. Dougan & Britt-Sabina Petersen & Espen Melum & Thomas Pertel & Kiera L. Clayton & Monika Raab &, 2015. "CEACAM1 regulates TIM-3-mediated tolerance and exhaustion," Nature, Nature, vol. 517(7534), pages 386-390, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7534:d:10.1038_nature13848
    DOI: 10.1038/nature13848
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    Cited by:

    1. Isabelle Rose Leo & Luay Aswad & Matthias Stahl & Elena Kunold & Frederik Post & Tom Erkers & Nona Struyf & Georgios Mermelekas & Rubin Narayan Joshi & Eva Gracia-Villacampa & Päivi Östling & Olli P. , 2022. "Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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