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EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway

Author

Listed:
  • Brent Neumann

    (CJCADR, Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia)

  • Sean Coakley

    (CJCADR, Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia)

  • Rosina Giordano-Santini

    (CJCADR, Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia)

  • Casey Linton

    (CJCADR, Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia)

  • Eui Seung Lee

    (Cellular, and Developmental Biology, University of Colorado)

  • Akihisa Nakagawa

    (Cellular, and Developmental Biology, University of Colorado)

  • Ding Xue

    (Cellular, and Developmental Biology, University of Colorado)

  • Massimo A. Hilliard

    (CJCADR, Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia)

Abstract

Unlike the limited post-injury neuronal regeneration in humans, severed axons in C. elegans can regenerate through a cellular fusion mechanism; this study identifies the molecular basis for this process which includes phosphatidylserine recognition and a role for specific molecules that also act in apoptosis.

Suggested Citation

  • Brent Neumann & Sean Coakley & Rosina Giordano-Santini & Casey Linton & Eui Seung Lee & Akihisa Nakagawa & Ding Xue & Massimo A. Hilliard, 2015. "EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway," Nature, Nature, vol. 517(7533), pages 219-222, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7533:d:10.1038_nature14102
    DOI: 10.1038/nature14102
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