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Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

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  • Antonina V. Kurtova

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Jing Xiao

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Qianxing Mo

    (Dan L Duncan Cancer Center and Center for Cell Gene & Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Senthil Pazhanisamy

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Ross Krasnow

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Seth P. Lerner

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Fengju Chen

    (Dan L Duncan Cancer Center and Center for Cell Gene & Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Terrence T. Roh

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Summer Medical and Research Training (SMART) Program, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Erica Lay

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Philip Levy Ho

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Keith Syson Chan

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Dan L Duncan Cancer Center and Center for Cell Gene & Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

Abstract

Using human bladder cancer xenograft models, a new mechanism involving an active proliferative response of cancer stem cells to chemotherapy-induced damage is shown, driven by prostaglandin E2 (PGE2) release in a manner similar to PGE2-induced wound repair; pharmacological inhibition of the PGE2/COX2 axis by celecoxib attenuates chemoresistance, suggesting a possible adjunctive therapy for bladder carcinomas.

Suggested Citation

  • Antonina V. Kurtova & Jing Xiao & Qianxing Mo & Senthil Pazhanisamy & Ross Krasnow & Seth P. Lerner & Fengju Chen & Terrence T. Roh & Erica Lay & Philip Levy Ho & Keith Syson Chan, 2015. "Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance," Nature, Nature, vol. 517(7533), pages 209-213, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7533:d:10.1038_nature14034
    DOI: 10.1038/nature14034
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    Cited by:

    1. Charlotte R. Bell & Victoria S. Pelly & Agrin Moeini & Shih-Chieh Chiang & Eimear Flanagan & Christian P. Bromley & Christopher Clark & Charles H. Earnshaw & Maria A. Koufaki & Eduardo Bonavita & Sant, 2022. "Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Fotis Nikolos & Kazukuni Hayashi & Xen Ping Hoi & Mark Ellie Alonzo & Qianxing Mo & Armine Kasabyan & Hideki Furuya & Jane Trepel & Dolores Vizio & Jlenia Guarnerio & Dan Theodorescu & Charles Rosser , 2022. "Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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