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T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

Author

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  • Dan Liu

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Heping Xu

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University
    Present addresses: Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA (H.X.); College of Life Sciences & Bioengineering, Jiaotong University, 100044 Beijing, China (D. Luo.).)

  • Changming Shih

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Zurong Wan

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Xiaopeng Ma

    (School of Life Sciences, Tsinghua University)

  • Weiwei Ma

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Dan Luo

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University
    Present addresses: Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA (H.X.); College of Life Sciences & Bioengineering, Jiaotong University, 100044 Beijing, China (D. Luo.).)

  • Hai Qi

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

Abstract

Interactions between T and B cells in the germinal centre are brief but involve extensive cell-surface contact in an entangled mode; ICOSL promotes T–B entanglement and B-cell acquisition of CD40L, which drives B cells to upregulate ICOSL, thus forming an intercellular feed-forward loop that is required for efficient positive selection and development of the bone marrow plasma cell compartment.

Suggested Citation

  • Dan Liu & Heping Xu & Changming Shih & Zurong Wan & Xiaopeng Ma & Weiwei Ma & Dan Luo & Hai Qi, 2015. "T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction," Nature, Nature, vol. 517(7533), pages 214-218, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7533:d:10.1038_nature13803
    DOI: 10.1038/nature13803
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    Cited by:

    1. Rabindra K. Mandal & Anita Mandal & Joshua E. Denny & Ruth Namazii & Chandy C. John & Nathan W. Schmidt, 2023. "Gut Bacteroides act in a microbial consortium to cause susceptibility to severe malaria," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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