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A PP1–PP2A phosphatase relay controls mitotic progression

Author

Listed:
  • Agnes Grallert

    (CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

  • Elvan Boke

    (CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
    Present address: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.)

  • Anja Hagting

    (The Gurdon Institute, Tennis Court Road, University of Cambridge, Cambridge, CB2 1QN, UK)

  • Ben Hodgson

    (CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

  • Yvonne Connolly

    (Biological Mass Spectrometry, CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

  • John R. Griffiths

    (Biological Mass Spectrometry, CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

  • Duncan L. Smith

    (Biological Mass Spectrometry, CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

  • Jonathon Pines

    (The Gurdon Institute, Tennis Court Road, University of Cambridge, Cambridge, CB2 1QN, UK)

  • Iain M. Hagan

    (CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

Abstract

The activation and coordination of phosphatase activity is important during mitotic exit; here, a mitotic phosphatase relay is described in fission yeast between the two major phosphatases, PP1 and PP2A, a mode of regulation that may be a feature of signalling networks across eukaryotes.

Suggested Citation

  • Agnes Grallert & Elvan Boke & Anja Hagting & Ben Hodgson & Yvonne Connolly & John R. Griffiths & Duncan L. Smith & Jonathon Pines & Iain M. Hagan, 2015. "A PP1–PP2A phosphatase relay controls mitotic progression," Nature, Nature, vol. 517(7532), pages 94-98, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7532:d:10.1038_nature14019
    DOI: 10.1038/nature14019
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