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Hepatitis A virus and the origins of picornaviruses

Author

Listed:
  • Xiangxi Wang

    (National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science)

  • Jingshan Ren

    (University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, UK)

  • Qiang Gao

    (National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
    Sinovac Biotech Co., Ltd)

  • Zhongyu Hu

    (National Institutes for Food and Drug Control, No. 2, TiantanXili, Beijing 100050, China)

  • Yao Sun

    (National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science)

  • Xuemei Li

    (National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science)

  • David J. Rowlands

    (Institute of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK)

  • Weidong Yin

    (Sinovac Biotech Co., Ltd)

  • Junzhi Wang

    (National Institutes for Food and Drug Control, No. 2, TiantanXili, Beijing 100050, China)

  • David I. Stuart

    (University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, UK
    Diamond Light Sources, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK)

  • Zihe Rao

    (National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
    Laboratory of Structural Biology, School of Medicine, Tsinghua University
    State Key Laboratory of Medicinal Chemical Biology, Nankai University)

  • Elizabeth E. Fry

    (University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, UK)

Abstract

Hepatitis A virus is a picornavirus that causes significant morbidity but remains poorly understood; this paper now provides high-resolution crystal structures of both the mature and the empty hepatitis A virus particle, which show that the three-dimensional structure resembles insect picorna-like viruses.

Suggested Citation

  • Xiangxi Wang & Jingshan Ren & Qiang Gao & Zhongyu Hu & Yao Sun & Xuemei Li & David J. Rowlands & Weidong Yin & Junzhi Wang & David I. Stuart & Zihe Rao & Elizabeth E. Fry, 2015. "Hepatitis A virus and the origins of picornaviruses," Nature, Nature, vol. 517(7532), pages 85-88, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7532:d:10.1038_nature13806
    DOI: 10.1038/nature13806
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