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Protein quality control at the inner nuclear membrane

Author

Listed:
  • Anton Khmelinskii

    (Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany)

  • Ewa Blaszczak

    (Centre National de la Recherche Scientifique, UMR 6290, 35000 Rennes, France
    Institut de Génétique et Développement de Rennes, Université de Rennes 1, 35000 Rennes, France)

  • Marina Pantazopoulou

    (The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20B, SE-106 91 Stockholm, Sweden)

  • Bernd Fischer

    (Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, 69117 Heidelberg, Germany
    Computational Genome Biology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany)

  • Deike J. Omnus

    (The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20B, SE-106 91 Stockholm, Sweden)

  • Gaëlle Le Dez

    (Centre National de la Recherche Scientifique, UMR 6290, 35000 Rennes, France
    Institut de Génétique et Développement de Rennes, Université de Rennes 1, 35000 Rennes, France)

  • Audrey Brossard

    (Centre National de la Recherche Scientifique, UMR 6290, 35000 Rennes, France
    Institut de Génétique et Développement de Rennes, Université de Rennes 1, 35000 Rennes, France)

  • Alexander Gunnarsson

    (The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20B, SE-106 91 Stockholm, Sweden)

  • Joseph D. Barry

    (Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, 69117 Heidelberg, Germany)

  • Matthias Meurer

    (Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany)

  • Daniel Kirrmaier

    (Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany)

  • Charles Boone

    (Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, Ontario M5S 3E1, Canada)

  • Wolfgang Huber

    (Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, 69117 Heidelberg, Germany)

  • Gwenaël Rabut

    (Centre National de la Recherche Scientifique, UMR 6290, 35000 Rennes, France
    Institut de Génétique et Développement de Rennes, Université de Rennes 1, 35000 Rennes, France)

  • Per O. Ljungdahl

    (The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20B, SE-106 91 Stockholm, Sweden)

  • Michael Knop

    (Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Cell Morphogenesis and Signal Transduction, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany)

Abstract

A protein degradation pathway is found at the inner nuclear membrane that is distinct from, but complementary to, endoplasmic-reticulum-associated protein degradation, and which is mediated by the Asi protein complex; a genome-wide library screening of yeast identifies more than 20 substrates of this pathway, which is shown to target mislocalized integral membrane proteins for degradation.

Suggested Citation

  • Anton Khmelinskii & Ewa Blaszczak & Marina Pantazopoulou & Bernd Fischer & Deike J. Omnus & Gaëlle Le Dez & Audrey Brossard & Alexander Gunnarsson & Joseph D. Barry & Matthias Meurer & Daniel Kirrmaie, 2014. "Protein quality control at the inner nuclear membrane," Nature, Nature, vol. 516(7531), pages 410-413, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7531:d:10.1038_nature14096
    DOI: 10.1038/nature14096
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    Cited by:

    1. Ka-Yiu Edwin Kong & Susmitha Shankar & Frank Rühle & Anton Khmelinskii, 2023. "Orphan quality control by an SCF ubiquitin ligase directed to pervasive C-degrons," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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