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Rapid modelling of cooperating genetic events in cancer through somatic genome editing

Author

Listed:
  • Francisco J. Sánchez-Rivera

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Thales Papagiannakopoulos

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Rodrigo Romero

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Tuomas Tammela

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Matthew R. Bauer

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Arjun Bhutkar

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Nikhil S. Joshi

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Lakshmipriya Subbaraj

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Roderick T. Bronson

    (Tufts University
    Harvard Medical School)

  • Wen Xue

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Tyler Jacks

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

Abstract

The CRISPR/Cas system has been used in mice for genome editing to introduce genetic alterations found in human lung tumours, and these genome modifications resulted in mouse lung tumours showing different histopathologies depending on the genes altered; the CRISPR/Cas system offers improved and faster ways to create animal models of human diseases such as cancer.

Suggested Citation

  • Francisco J. Sánchez-Rivera & Thales Papagiannakopoulos & Rodrigo Romero & Tuomas Tammela & Matthew R. Bauer & Arjun Bhutkar & Nikhil S. Joshi & Lakshmipriya Subbaraj & Roderick T. Bronson & Wen Xue &, 2014. "Rapid modelling of cooperating genetic events in cancer through somatic genome editing," Nature, Nature, vol. 516(7531), pages 428-431, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7531:d:10.1038_nature13906
    DOI: 10.1038/nature13906
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