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Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

Author

Listed:
  • Kyle W. McCracken

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA)

  • Emily M. Catá

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA)

  • Calyn M. Crawford

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA)

  • Katie L. Sinagoga

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA)

  • Michael Schumacher

    (University of Cincinnati)

  • Briana E. Rockich

    (University of Michigan Medical School)

  • Yu-Hwai Tsai

    (University of Michigan Medical School)

  • Christopher N. Mayhew

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA)

  • Jason R. Spence

    (University of Michigan Medical School
    University of Michigan Medical School)

  • Yana Zavros

    (University of Cincinnati)

  • James M. Wells

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
    Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA)

Abstract

The in vitro generation, from pluripotent stem cells, of three-dimensional human gastric organoids (hGOs) that contain a physiological gastric epithelium comprising both progenitor and differentiated cell types, and have expected functional characteristics is described, as is modelling the pathophysiological response of the human stomach to Helicobacter pylori using these hGOs.

Suggested Citation

  • Kyle W. McCracken & Emily M. Catá & Calyn M. Crawford & Katie L. Sinagoga & Michael Schumacher & Briana E. Rockich & Yu-Hwai Tsai & Christopher N. Mayhew & Jason R. Spence & Yana Zavros & James M. Wel, 2014. "Modelling human development and disease in pluripotent stem-cell-derived gastric organoids," Nature, Nature, vol. 516(7531), pages 400-404, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7531:d:10.1038_nature13863
    DOI: 10.1038/nature13863
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    Cited by:

    1. Shizuka Miura & Kenichi Horisawa & Tokuko Iwamori & Satoshi Tsujino & Kazuya Inoue & Satsuki Karasawa & Junpei Yamamoto & Yasuyuki Ohkawa & Sayaka Sekiya & Atsushi Suzuki, 2024. "Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in culture," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Bas Loo & Simone A. Den & Nuno Araújo-Gomes & Vincent Jong & Rebecca R. Snabel & Maik Schot & José M. Rivera-Arbeláez & Gert Jan C. Veenstra & Robert Passier & Tom Kamperman & Jeroen Leijten, 2023. "Mass production of lumenogenic human embryoid bodies and functional cardiospheres using in-air-generated microcapsules," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Feng Lin & Xia Li & Shiyu Sun & Zhongyi Li & Chenglin Lv & Jianbo Bai & Lin Song & Yizhao Han & Bo Li & Jianping Fu & Yue Shao, 2023. "Mechanically enhanced biogenesis of gut spheroids with instability-driven morphomechanics," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Giovanni Giuseppe Giobbe & Francesco Bonfante & Brendan C. Jones & Onelia Gagliano & Camilla Luni & Elisa Zambaiti & Silvia Perin & Cecilia Laterza & Georg Busslinger & Hannah Stuart & Matteo Pagliari, 2021. "SARS-CoV-2 infection and replication in human gastric organoids," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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