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Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe

Author

Listed:
  • Takeshi Mizuguchi

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Geoffrey Fudenberg

    (Graduate Program in Biophysics, Harvard University
    Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology)

  • Sameet Mehta

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Jon-Matthew Belton

    (Program in Systems Biology, University of Massachusetts Medical School)

  • Nitika Taneja

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Hernan Diego Folco

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Peter FitzGerald

    (Genome Analysis Unit, National Cancer Institute, National Institutes of Health)

  • Job Dekker

    (Program in Systems Biology, University of Massachusetts Medical School)

  • Leonid Mirny

    (Graduate Program in Biophysics, Harvard University
    Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology)

  • Jemima Barrowman

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Shiv I. S. Grewal

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

Abstract

Genome-wide chromatin conformation capture (Hi-C) is used to investigate three-dimensional genome organization in Schizosaccharomyces pombe; small domains of chromatin interact locally on chromosome arms to form globules, which depend on cohesin but not heterochromatin for formation, and heterochromatin at centromeres and telomeres provides crucial structural constraints to shape genome architecture.

Suggested Citation

  • Takeshi Mizuguchi & Geoffrey Fudenberg & Sameet Mehta & Jon-Matthew Belton & Nitika Taneja & Hernan Diego Folco & Peter FitzGerald & Job Dekker & Leonid Mirny & Jemima Barrowman & Shiv I. S. Grewal, 2014. "Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe," Nature, Nature, vol. 516(7531), pages 432-435, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7531:d:10.1038_nature13833
    DOI: 10.1038/nature13833
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    Cited by:

    1. David E. Torres & H. Martin Kramer & Vittorio Tracanna & Gabriel L. Fiorin & David E. Cook & Michael F. Seidl & Bart P. H. J. Thomma, 2024. "Implications of the three-dimensional chromatin organization for genome evolution in a fungal plant pathogen," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Wu Zuo & Guangming Chen & Zhimei Gao & Shuai Li & Yanyan Chen & Chenhui Huang & Juan Chen & Zhengjun Chen & Ming Lei & Qian Bian, 2021. "Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment," Nature Communications, Nature, vol. 12(1), pages 1-20, December.

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