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Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

Author

Listed:
  • Jichang Wang

    (Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany)

  • Gangcai Xie

    (Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
    Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yueyang Road, Shanghai 200031, China)

  • Manvendra Singh

    (Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany)

  • Avazeh T. Ghanbarian

    (University of Bath, Bath, Somerset BA2 7AY, UK)

  • Tamás Raskó

    (Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany)

  • Attila Szvetnik

    (Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany)

  • Huiqiang Cai

    (Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany)

  • Daniel Besser

    (Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany)

  • Alessandro Prigione

    (Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany)

  • Nina V. Fuchs

    (Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
    Paul-Ehrlich-Institute, Paul-Ehrlich-Strasse 51-59, 63225 Langen, Germany)

  • Gerald G. Schumann

    (Paul-Ehrlich-Institute, Paul-Ehrlich-Strasse 51-59, 63225 Langen, Germany)

  • Wei Chen

    (Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany)

  • Matthew C. Lorincz

    (University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada)

  • Zoltán Ivics

    (Paul-Ehrlich-Institute, Paul-Ehrlich-Strasse 51-59, 63225 Langen, Germany)

  • Laurence D. Hurst

    (University of Bath, Bath, Somerset BA2 7AY, UK)

  • Zsuzsanna Izsvák

    (Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany)

Abstract

An extensive analysis of HERVH (a primate-specific endogenous retrovirus) expression in human pluripotent stem cells is presented, identifying a sub-population of cells within cultured human embryonic stem cells and induced pluripotent stem cells that has characteristics of naive-state cells — the study provides evidence for a new primate-specific transcriptional circuitry regulating pluripotency.

Suggested Citation

  • Jichang Wang & Gangcai Xie & Manvendra Singh & Avazeh T. Ghanbarian & Tamás Raskó & Attila Szvetnik & Huiqiang Cai & Daniel Besser & Alessandro Prigione & Nina V. Fuchs & Gerald G. Schumann & Wei Chen, 2014. "Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells," Nature, Nature, vol. 516(7531), pages 405-409, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7531:d:10.1038_nature13804
    DOI: 10.1038/nature13804
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