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Rapid development of broadly influenza neutralizing antibodies through redundant mutations

Author

Listed:
  • Leontios Pappas

    (Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Mathilde Foglierini

    (Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Luca Piccoli

    (Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Nicole L. Kallewaard

    (One MedImmune Way)

  • Filippo Turrini

    (Viral Pathogens and Biosafety Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy)

  • Chiara Silacci

    (Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Blanca Fernandez-Rodriguez

    (Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Gloria Agatic

    (Humabs BioMed SA, Via Mirasole 1, 6500 Bellinzona, Switzerland)

  • Isabella Giacchetto-Sasselli

    (Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Gabriele Pellicciotta

    (Unit of Preventive Medicine, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy)

  • Federica Sallusto

    (Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland)

  • Qing Zhu

    (One MedImmune Way)

  • Elisa Vicenzi

    (Viral Pathogens and Biosafety Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy)

  • Davide Corti

    (Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
    Humabs BioMed SA, Via Mirasole 1, 6500 Bellinzona, Switzerland)

  • Antonio Lanzavecchia

    (Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
    Insitute for Microbiology, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland)

Abstract

The main pathway of somatic mutations leading to the generation of high affinity broadly neutralizing antibodies against the influenza haemagglutinin stem is defined.

Suggested Citation

  • Leontios Pappas & Mathilde Foglierini & Luca Piccoli & Nicole L. Kallewaard & Filippo Turrini & Chiara Silacci & Blanca Fernandez-Rodriguez & Gloria Agatic & Isabella Giacchetto-Sasselli & Gabriele Pe, 2014. "Rapid development of broadly influenza neutralizing antibodies through redundant mutations," Nature, Nature, vol. 516(7531), pages 418-422, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7531:d:10.1038_nature13764
    DOI: 10.1038/nature13764
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