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Dietary modulation of the microbiome affects autoinflammatory disease

Author

Listed:
  • John R. Lukens

    (St Jude Children’s Research Hospital)

  • Prajwal Gurung

    (St Jude Children’s Research Hospital)

  • Peter Vogel

    (Animal Resources Center and the Veterinary Pathology Core, St Jude Children’s Research Hospital)

  • Gordon R. Johnson

    (St Jude Children’s Research Hospital)

  • Robert A. Carter

    (Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital)

  • Daniel J. McGoldrick

    (Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital)

  • Srinivasa Rao Bandi

    (St Jude Children’s Research Hospital)

  • Christopher R. Calabrese

    (Small Animal Imaging Core, St Jude Children’s Research Hospital)

  • Lieselotte Vande Walle

    (VIB, B-9000 Ghent, Belgium
    Ghent University, B-9000 Ghent, Belgium)

  • Mohamed Lamkanfi

    (VIB, B-9000 Ghent, Belgium
    Ghent University, B-9000 Ghent, Belgium)

  • Thirumala-Devi Kanneganti

    (St Jude Children’s Research Hospital)

Abstract

Pstpip2-mutant mice fed a high-fat diet are protected against inflammatory bone disease and bone erosion; this protection is associated with reductions in intestinal Prevotella levels and pro-IL-1β expression, and is dependent on the deletion of both caspases 1 and 8.

Suggested Citation

  • John R. Lukens & Prajwal Gurung & Peter Vogel & Gordon R. Johnson & Robert A. Carter & Daniel J. McGoldrick & Srinivasa Rao Bandi & Christopher R. Calabrese & Lieselotte Vande Walle & Mohamed Lamkanfi, 2014. "Dietary modulation of the microbiome affects autoinflammatory disease," Nature, Nature, vol. 516(7530), pages 246-249, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7530:d:10.1038_nature13788
    DOI: 10.1038/nature13788
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    Cited by:

    1. Joo-Hui Han & Rajendra Karki & R. K. Subbarao Malireddi & Raghvendra Mall & Roman Sarkar & Bhesh Raj Sharma & Jonathon Klein & Harmut Berns & Harshan Pisharath & Shondra M. Pruett-Miller & Sung-Jin Ba, 2024. "NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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