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An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons

Author

Listed:
  • Frank M. J. Jacobs

    (Center for Biomolecular Science and Engineering, University of California Santa Cruz
    Present addresses: Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098 XH, The Netherlands (F.M.J.J.); Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA (D.G.); Mater Research Institute, University of Queensland, Queensland 4101, Australia (A.D.E.).)

  • David Greenberg

    (Center for Biomolecular Science and Engineering, University of California Santa Cruz
    Molecular, Cell and Developmental Biology, University of California Santa Cruz
    Present addresses: Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098 XH, The Netherlands (F.M.J.J.); Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA (D.G.); Mater Research Institute, University of Queensland, Queensland 4101, Australia (A.D.E.).)

  • Ngan Nguyen

    (Center for Biomolecular Science and Engineering, University of California Santa Cruz
    Biomolecular Engineering, University of California Santa Cruz)

  • Maximilian Haeussler

    (Center for Biomolecular Science and Engineering, University of California Santa Cruz)

  • Adam D. Ewing

    (Center for Biomolecular Science and Engineering, University of California Santa Cruz
    Present addresses: Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098 XH, The Netherlands (F.M.J.J.); Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA (D.G.); Mater Research Institute, University of Queensland, Queensland 4101, Australia (A.D.E.).)

  • Sol Katzman

    (Center for Biomolecular Science and Engineering, University of California Santa Cruz)

  • Benedict Paten

    (Center for Biomolecular Science and Engineering, University of California Santa Cruz)

  • Sofie R. Salama

    (Center for Biomolecular Science and Engineering, University of California Santa Cruz
    Howard Hughes Medical Institute, University of California Santa Cruz)

  • David Haussler

    (Center for Biomolecular Science and Engineering, University of California Santa Cruz
    Howard Hughes Medical Institute, University of California Santa Cruz)

Abstract

The authors show that two primate-specific genes encoding KRAB domain containing zinc finger proteins, ZNF91 and ZNF93, have evolved during the last 25 million years to repress retrotransposon families that emerged during this time period; according to the new data KZNF gene expansion limits the activity of newly emerged retrotransposons, which subsequently mutate to evade repression.

Suggested Citation

  • Frank M. J. Jacobs & David Greenberg & Ngan Nguyen & Maximilian Haeussler & Adam D. Ewing & Sol Katzman & Benedict Paten & Sofie R. Salama & David Haussler, 2014. "An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons," Nature, Nature, vol. 516(7530), pages 242-245, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7530:d:10.1038_nature13760
    DOI: 10.1038/nature13760
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