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Nutrient-sensing nuclear receptors coordinate autophagy

Author

Listed:
  • Jae Man Lee

    (Baylor College of Medicine)

  • Martin Wagner

    (Baylor College of Medicine
    Present addresses: Laboratory of Experimental Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A-8036 Graz, Austria (M.W.); Stanford University School of Medicine, Palo Alto, California 94305, USA (D.F.).)

  • Rui Xiao

    (Baylor College of Medicine)

  • Kang Ho Kim

    (Baylor College of Medicine)

  • Dan Feng

    (Diabetes, and Metabolism and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Present addresses: Laboratory of Experimental Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A-8036 Graz, Austria (M.W.); Stanford University School of Medicine, Palo Alto, California 94305, USA (D.F.).)

  • Mitchell A. Lazar

    (Diabetes, and Metabolism and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • David D. Moore

    (Baylor College of Medicine)

Abstract

The nuclear receptors FXR and PPARα are shown to regulate autophagy by competing for binding to shared sites in the promoters of autophagic genes; in the fed state FXR suppresses hepatic autophagy, whereas in the fasted state PPARα is activated and reverses the normal suppression of autophagy.

Suggested Citation

  • Jae Man Lee & Martin Wagner & Rui Xiao & Kang Ho Kim & Dan Feng & Mitchell A. Lazar & David D. Moore, 2014. "Nutrient-sensing nuclear receptors coordinate autophagy," Nature, Nature, vol. 516(7529), pages 112-115, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7529:d:10.1038_nature13961
    DOI: 10.1038/nature13961
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    Cited by:

    1. Hui Xia & Catherine R. Dufour & Younes Medkour & Charlotte Scholtes & Yonghong Chen & Christina Guluzian & Wafa B’chir & Vincent Giguère, 2023. "Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice," Nature Communications, Nature, vol. 14(1), pages 1-24, December.
    2. Danielle M. Smith & Brian Y. Liu & Michael J. Wolfgang, 2024. "Rab30 facilitates lipid homeostasis during fasting," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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