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The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

Author

Listed:
  • Tamás Matusek

    (Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
    CNRS, iBV, UMR 7277, 06100 Nice, France
    INSERM, iBV, U1091, 06100 Nice, France)

  • Franz Wendler

    (Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
    CNRS, iBV, UMR 7277, 06100 Nice, France
    INSERM, iBV, U1091, 06100 Nice, France)

  • Sophie Polès

    (Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
    CNRS, iBV, UMR 7277, 06100 Nice, France
    INSERM, iBV, U1091, 06100 Nice, France)

  • Sandrine Pizette

    (Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
    CNRS, iBV, UMR 7277, 06100 Nice, France
    INSERM, iBV, U1091, 06100 Nice, France)

  • Gisela D’Angelo

    (Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
    CNRS, iBV, UMR 7277, 06100 Nice, France
    INSERM, iBV, U1091, 06100 Nice, France)

  • Maximilian Fürthauer

    (Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
    CNRS, iBV, UMR 7277, 06100 Nice, France
    INSERM, iBV, U1091, 06100 Nice, France)

  • Pascal P. Thérond

    (Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
    CNRS, iBV, UMR 7277, 06100 Nice, France
    INSERM, iBV, U1091, 06100 Nice, France)

Abstract

A new role for the endosomal sorting complex required for transport (ESCRT) is identified in fly larvae, where it is shown to be essential for the secretion and long-range signalling of the embryonic development morphogen Hedgehog.

Suggested Citation

  • Tamás Matusek & Franz Wendler & Sophie Polès & Sandrine Pizette & Gisela D’Angelo & Maximilian Fürthauer & Pascal P. Thérond, 2014. "The ESCRT machinery regulates the secretion and long-range activity of Hedgehog," Nature, Nature, vol. 516(7529), pages 99-103, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7529:d:10.1038_nature13847
    DOI: 10.1038/nature13847
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    Cited by:

    1. Tomoyuki Hatano & Saravanan Palani & Dimitra Papatziamou & Ralf Salzer & Diorge P. Souza & Daniel Tamarit & Mehul Makwana & Antonia Potter & Alexandra Haig & Wenjue Xu & David Townsend & David Rochest, 2022. "Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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