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PD-1 blockade induces responses by inhibiting adaptive immune resistance

Author

Listed:
  • Paul C. Tumeh

    (University of California Los Angeles (UCLA)
    Jonsson Comprehensive Cancer Center)

  • Christina L. Harview

    (University of California Los Angeles (UCLA))

  • Jennifer H. Yearley

    (Merck & Co)

  • I. Peter Shintaku

    (University of California Los Angeles (UCLA))

  • Emma J. M. Taylor

    (University of California Los Angeles (UCLA))

  • Lidia Robert

    (University of California Los Angeles (UCLA))

  • Bartosz Chmielowski

    (University of California Los Angeles (UCLA)
    Jonsson Comprehensive Cancer Center)

  • Marko Spasic

    (University of California Los Angeles (UCLA))

  • Gina Henry

    (University of California Los Angeles (UCLA))

  • Voicu Ciobanu

    (University of California Los Angeles (UCLA))

  • Alisha N. West

    (University of California Los Angeles (UCLA))

  • Manuel Carmona

    (University of California Los Angeles (UCLA))

  • Christine Kivork

    (University of California Los Angeles (UCLA))

  • Elizabeth Seja

    (University of California Los Angeles (UCLA))

  • Grace Cherry

    (University of California Los Angeles (UCLA))

  • Antonio J. Gutierrez

    (University of California Los Angeles (UCLA))

  • Tristan R. Grogan

    (University of California Los Angeles (UCLA))

  • Christine Mateus

    (Gustave Roussy and INSERM U981, Villejuif, Paris Sud, France)

  • Gorana Tomasic

    (Gustave Roussy and INSERM U981, Villejuif, Paris Sud, France)

  • John A. Glaspy

    (University of California Los Angeles (UCLA)
    Jonsson Comprehensive Cancer Center)

  • Ryan O. Emerson

    (Adaptive Biotechnologies)

  • Harlan Robins

    (Adaptive Biotechnologies
    Fred Hutchinson Cancer Research Center)

  • Robert H. Pierce

    (Merck & Co)

  • David A. Elashoff

    (University of California Los Angeles (UCLA)
    Jonsson Comprehensive Cancer Center)

  • Caroline Robert

    (Gustave Roussy and INSERM U981, Villejuif, Paris Sud, France)

  • Antoni Ribas

    (University of California Los Angeles (UCLA)
    Jonsson Comprehensive Cancer Center)

Abstract

The dynamics of T-cell responses are investigated in tumour tissue from patients with advanced melanoma who were treated with a PD-1-blocking monoclonal antibody, revealing that clinical efficacy of the treatment correlates with increased frequencies of pre-existing CD8+ T cells and PD-1 and PD-L1 expression.

Suggested Citation

  • Paul C. Tumeh & Christina L. Harview & Jennifer H. Yearley & I. Peter Shintaku & Emma J. M. Taylor & Lidia Robert & Bartosz Chmielowski & Marko Spasic & Gina Henry & Voicu Ciobanu & Alisha N. West & M, 2014. "PD-1 blockade induces responses by inhibiting adaptive immune resistance," Nature, Nature, vol. 515(7528), pages 568-571, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7528:d:10.1038_nature13954
    DOI: 10.1038/nature13954
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