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A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealing

Author

Listed:
  • Sarah B. Miller

    (Harvard University
    Present address: Department of Biology, Georgetown University, Washington DC 20057, USA.)

  • F. Zehra Yildiz

    (Harvard University)

  • Jennifer A. Lo

    (Harvard University)

  • Bo Wang

    (Harvard University)

  • Victoria M. D’Souza

    (Harvard University)

Abstract

To prime reverse transcription of Moloney murine leukaemia virus, a transfer RNA molecule must bind two regions of the retroviral RNA, the primer binding site (PBS) and primer activation signal within the U5-PBS; here, the NMR structures of the U5-PBS RNA and tRNA primer are solved, with and without the retroviral nucleocapsid protein, which remodels these regions.

Suggested Citation

  • Sarah B. Miller & F. Zehra Yildiz & Jennifer A. Lo & Bo Wang & Victoria M. D’Souza, 2014. "A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealing," Nature, Nature, vol. 515(7528), pages 591-595, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7528:d:10.1038_nature13709
    DOI: 10.1038/nature13709
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