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Synaptic dysregulation in a human iPS cell model of mental disorders

Author

Listed:
  • Zhexing Wen

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Ha Nam Nguyen

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine)

  • Ziyuan Guo

    (Huck Institutes of Life Sciences, The Pennsylvania State University, University Park)

  • Matthew A. Lalli

    (Neuroscience Research Institute, Biomolecular Science and Engineering Program, University of California)

  • Xinyuan Wang

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    School of Basic Medical Sciences, Fudan University)

  • Yijing Su

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Nam-Shik Kim

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Ki-Jun Yoon

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Jaehoon Shin

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine)

  • Ce Zhang

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Georgia Makri

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • David Nauen

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Huimei Yu

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Elmer Guzman

    (Neuroscience Research Institute, Biomolecular Science and Engineering Program, University of California)

  • Cheng-Hsuan Chiang

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Nadine Yoritomo

    (Johns Hopkins University School of Medicine)

  • Kozo Kaibuchi

    (Nagoya University Graduate School of Medicine, Showa, Nagoya 466-8550, Japan)

  • Jizhong Zou

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Kimberly M. Christian

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Linzhao Cheng

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Christopher A. Ross

    (Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Russell L. Margolis

    (Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Gong Chen

    (Huck Institutes of Life Sciences, The Pennsylvania State University, University Park)

  • Kenneth S. Kosik

    (Neuroscience Research Institute, Biomolecular Science and Engineering Program, University of California)

  • Hongjun Song

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Guo-li Ming

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

Abstract

Generation and neural differentiation of induced pluripotent stem cells (iPS cells) from patients enables new ways to investigate the cellular pathophysiology of mental disorders; this approach was used with samples from a family with a schizophrenia pedigree and a DISC1 mutation, revealing synaptic abnormalities and large-scale transcriptional dysregulation.

Suggested Citation

  • Zhexing Wen & Ha Nam Nguyen & Ziyuan Guo & Matthew A. Lalli & Xinyuan Wang & Yijing Su & Nam-Shik Kim & Ki-Jun Yoon & Jaehoon Shin & Ce Zhang & Georgia Makri & David Nauen & Huimei Yu & Elmer Guzman &, 2014. "Synaptic dysregulation in a human iPS cell model of mental disorders," Nature, Nature, vol. 515(7527), pages 414-418, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7527:d:10.1038_nature13716
    DOI: 10.1038/nature13716
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